Dementia Care Research and Psychosocial Factors.

Background: The deficit of unawareness of cognitive impairment (cognitive anosognosia) is known to be associated with adverse health outcomes, caregiver burden, and worse cognitive outcomes. A better understanding of cognitive self-awareness and the ability to self-judge cognitive performance among the general population would enable a rational design of cognitive screening and improve how subjective cognitive decline and self-reported errors at tasks like medication administration are interpreted.

Method: Participants were enrolled in the Framingham Heart Study, which is a community-based cohort with three generations of participants.

Exogenous estradiol impacts anxiety-like behavior of juvenile male and female Siberian hamsters in a dose-dependent manner.

Anxiety is among the most prevalent mental health issues in children. While it is well established that gonadal steroids influence anxiety-like behavior in adulthood, a potential role in prepubertal juveniles has been overlooked because it is commonly thought that the gonads are quiescent during the juvenile period. However, the juvenile gonads secrete measurable amounts of steroids, and we have recently found that prepubertal ovariectomy decreases anxiety-like behavior of juvenile Siberian hamsters in the light/dark box test.

How to … Build a Peer Reviewer Community in Health Professions Education.

Peer review is the cornerstone of academic publishing that upholds the quality and integrity of scholarly work. However, there is an ever-growing struggle to recruit peer reviewers, termed the 'peer review crisis', driven by a shrinking academic workforce and increased workload. Additionally, there is a notable lack of standardised training for peer reviewers which poses a challenge in maintaining high-quality reviews.

GP emigration from Ireland: an analysis of data from key destination countries.

Background: Ireland is experiencing a general practitioner (GP) workforce crisis, facing an ageing workforce, a growing population with increased life expectancy, and increased complexity of patients. The GP crisis threatens access to primary care in Ireland, as well as Ireland's aim to transform into a primary-care centred system of universal healthcare via the proposed "Sláintecare" healthcare reforms. The challenges faced are common to many countries as health systems seek to expand their medical workforce post-pandemic.

Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer.

Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Despite advances in diagnosis and treatment, including surgery, chemotherapy, and immunotherapy, accurate clinical markers are still lacking. The development of prognostic and predictive indicators, particularly in the context of personalized medicine, could significantly improve CRC patient management.