[Intensity of lipid peroxidation and its relation to changes in the composition and antioxidative properties of lipids in acute viral hepatitis].

Interrelationship between the patterns of lipid peroxidation (diene conjugates and the lipid antioxidative activity) and alterations in lipid composition (content of total lipids, phospholipids and cholesterol) was studied in blood serum of patients with acute viral hepatitis and in healthy donors. An increase in content of lipids in blood serum of the patients with the hepatitis but not the intensity of peroxidation reactions in lipids was found to be responsible for the increase in content of the lipid peroxidation products in blood serum. With an increase in severity of the disease relative content of phospholipids in the total lipid fraction as well as antioxidative activity of lipids were elevated, while relative content of cholesterol and level of lipid oxidation were lowered.

[Characteristics of immune response regulation in viral hepatitis A and B].

In 272 patients with virus hepatitis A and B the content of theophylline-sensitive lymphocytes (T-suppressors) and theophylline-resistant lymphocytes (T-helpers) in the peripheral blood was determined. Differences in the content of T-suppressors in cases of acute virus hepatitis A and B with an equal degree of severity were revealed: at the peak of hepatitis A infection in the mild form of the disease the number of the cells was decreased, while at the peak of hepatitis B infection an increase in their number was observed in the mild and moderate forms of the disease and a decrease, in the severe form of the disease. In chronic persistent hepatitis a decrease in the content of T-suppressors and an increase in the content of T-helpers were observed, and in chronic active hepatitis (at the period of remission) and increase in the T-helpers occurred.