Addictive behavior among young people in Ukraine: a pilot study.

The AUDIT-like tests system was created for complex assessment and evaluation of the addictive status of adolescents in a Ukrainian population. The AUDIT-like tests system has been created from the Alcohol Use Disorders Identification Test (AUDIT) developed by the World Health Organization. The AUDIT-like tests were minimally modified from the original AUDIT.

[Changes in the lipoprotein metabolism in alcoholism do not recover during of prolonged remission].

Contents of lipoproteins (LP), activity of lipoprotein lipase (LP-lipase) and cholesterol esterification activity of blood serum were examined in patients with alcoholism at the periods of intoxication, alcohol abstinence and under conditions of prolonged remission. During remission a general pattern of apoB-containing LP was similar to the period of intoxication. Processes of transformation of this class LP significantly delayed in isolated blood serum in vitro.

[Depression of serum esterase and lipoprotein lipase activities in acute and longitudinal actions of ethanol].

Esterase (LCAT) and lipoprotein lipase (LPL) activities of blood serum, and a range of blood serum lipoproteins (LP) in acute and chronic ethanol intoxication were examined in healthy persons and patients with alcohol abuse. Ethanol inhibited LCAT and LPL activities, and increased apoA-containing LP in blood serum. These changes are considered as a basis for depression of a direct and reverse transportation of cholesterol in blood circulation under the action of ethanol.

[Dynamics of redistribution of blood serum lipoproteins in patients with alcoholism during alcohol intoxication and its abolition].

In the patients with alcoholism at intoxication and different periods of alcohol abolition the blood serum lipoproteins were investigated by a method of gradient gel-electrophoresis using the computer program for qualitative definition. It was found out that change of the total sum of all lipoprotein fractions was approximated to parabolic dependence with maximum in the 3rd day after alcohol abolition. Under intoxication disturbances the individual apoB-containing fractions were minimal as compared with the control, while at the initial stages of alcohol abolition their redistribution was noticed as reflecting the growth of the processes of cholesterol transportation from liver to peripheral tissues.

[The prevalence of cardiovascular pathology in alcoholism patients].

ECG was made in 336 patients with alcoholism that were admitted in a special hospital for alcoholic patients during one year. 146 patients were examined in the state of alcohol withdrawal syndrome, after its arrest and in stress. A prevalence of ECG changes well as stability of such alterations, prognostic criteria for a further course of both alcoholism and cardiovascular pathology were determined.