Pathogens spread by high-altitude windborne mosquitoes.

Recent studies have revealed that many mosquito species regularly engage in high-altitude windborne migration, but its epidemiological significance was debated. The hypothesis that high-altitude mosquitoes spread pathogens over large distances has not been directly tested. Here, we report for the first time that high-altitude windborne mosquitoes are commonly infected with arboviruses, protozoans, and helminths affecting vertebrates and humans, and provide the first description of this pathogen-vector aerial network.

Challenges of female microbial ecologists at different stages of their academic life: a Mexican perspective.

Latin American women scientists face a double glass ceiling because of cultural, institutional, and geographic biases, including those from international journal editors. Despite under-representation, they advance in science, technology, engineering, and mathematics (STEM), particularly microbiology. In Mexico, more efforts are needed to create an inclusive community, driving progress enriched by women's perspectives in science.

EphA4 Mediates EphrinB1-Dependent Adhesion in Retinal Ganglion Cells.

Eph/ephrin signaling is crucial for organizing retinotopic maps in vertebrates. Unlike other EphAs, which are expressed in the embryonic ventral retina, EphA4 is found in the retinal ganglion cell (RGC) layer at perinatal stages, and its role in mammalian visual system development remains unclear. Using classic in vitro stripe assays, we demonstrate that, while RGC axons are repelled by ephrinB2, they grow on ephrinB1 stripes through EphA4-mediated adhesion.

1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from (BDF3).

Chagas disease, caused by the protozoan parasite , affects millions globally, with increasing urban cases outside of Latin America. Treatment is based on two compounds, namely, benznidazole (BZ) and nifurtimox, but chronic cases pose several challenges. Targeting lysine acetylation, particularly bromodomain-containing proteins, shows promise as a novel antiparasitic target.

Analysis of the Probiotic Potential of LB1_P46 Isolated from the Mexican Fermented Pulque Beverage: A Functional and Genomic Analysis.

The traditional Mexican fermented beverage pulque has been considered a healthy product for treating gastrointestinal disorders. Lactic acid bacteria (LAB) have been identified as one of the most abundant microbial groups during pulque fermentation. As traditional pulque is consumed directly from the fermentation vessel, the naturally associated LABs are ingested, reaching the consumer's small intestine alive, suggesting their potential probiotic capability.