Publications by authors named "A Enomoto"
Systemic artery-to-pulmonary artery fistula (SAPAF) is an uncommon abnormal vascular connection between systemic and pulmonary arteries. SAPAF with 3 or more inflow vessels has rarely been reported. The definitive diagnosis is made by selective arterial angiography, but 3-dimensional computed tomography angiography is useful for delineating abnormal vessels.
View Article and Find Full Text PDFArticle Synopsis
- Brown adipose tissue (BAT) is critical for energy consumption, and its dysfunction can lead to metabolic diseases and obesity, especially as we age.
- The study identifies that perineurial cells, which have reduced antioxidant capacity due to lacking superoxide dismutase 2, impair BAT function by causing sympathetic nerve denervation and reducing fat oxidation.
- Targeting Meflin-expressing stromal cells may be a promising strategy to strengthen BAT function and combat age-related metabolic issues.
Protein phosphorylation, controlled by protein kinases, is central to regulating various pathophysiological processes, including cardiac systolic function. The dysregulation of protein kinase activity plays a significant role in the pathogenesis of cardiac systolic dysfunction. While cardiac contraction mechanisms are well documented, the mechanisms underlying cardiac diastole remain elusive.
View Article and Find Full Text PDFChronic fibrotic tissue disrupts various organ functions. Despite significant advances in therapies, mortality and morbidity due to heart failure remain high, resulting in poor quality of life. Beyond the cardiomyocyte-centric view of heart failure, it is now accepted that alterations in the interstitial extracellular matrix (ECM) also play a major role in the development of heart failure.
View Article and Find Full Text PDFArticle Synopsis
- - The case discusses a rare instance of pulmonary metastasis from renal angiomyolipoma (AML) in an 82-year-old woman, highlighting the need to differentiate between multicentric growth and true metastasis.
- - This patient had pulmonary nodules that were uniquely composed of fat, and her condition remained benign over a decade, emphasizing the atypical behavior of AML.
- - Whole-exome sequencing revealed specific mutations in the lung lesions, including a TSC2 mutation not found in her blood, suggesting that these lesions originated from her renal AML, which underscores the importance of recognizing such presentations for better diagnosis and treatment.