Publications by authors named "A Elton"
Heparan sulfate (HS) is an anionic polysaccharide generated by all animal cells, but our understanding of its roles in human pluripotent stem cell (hPSC) self-renewal and differentiation is limited. We derived HS-deficient hPSCs by disrupting the EXT1 glycosyltransferase. These EXT1 hPSCs maintain self-renewal and pluripotency under standard culture conditions that contain high levels of basic fibroblast growth factor(bFGF), a requirement for sufficient bFGF signaling in the engineered cells.
View Article and Find Full Text PDFLongitudinal studies of the effects of adversity on human brain development are complicated by the association of stressful events with confounding variables. To counter this bias, we apply a propensity-weighted analysis of the first two years of The Adolescent Brain Cognitive Development (ABCD) Study® data, employing a machine learning analysis weighted by individuals' propensity to experience adversity. Data included 338 resting-state functional connections from 7190 youth (46% female), divided into a training group (80%) and an independent testing group (20%).
View Article and Find Full Text PDFAn investigation of multimodal predictors of adolescent alcohol initiation.
Drug Alcohol Depend
December 2024
Article Synopsis
- Early alcohol initiation is linked to negative outcomes, and this study aims to identify and compare the importance of risk factors such as inhibition control, reward sensitivity, and contextual influences on early alcohol use.
- The analysis uses data from the ABCD Study involving nearly 12,000 youth, comparing those who began drinking before age 16 with similar peers who did not.
- Results indicate that contextual factors, like externalizing behaviors and prior substance knowledge, are the strongest predictors of early alcohol initiation, with inhibition control and reward sensitivity showing less relevance.
Longitudinal studies of the effects of adversity on human brain development are complicated by the association of stressful events with confounding variables. To counter this bias, we apply a propensity-weighted analysis of the first two years of The Adolescent Brain Cognitive Development (ABCD) Study data, employing a machine learning analysis weighted by individuals' propensity to experience adversity. Data included 338 resting-state functional connections from 7190 youth (46% female), divided into a training group (80%) and an independent testing group (20%).
View Article and Find Full Text PDFAim: While the United States is becoming increasingly Multiracial, much is still unknown about the behavioral health of these growing new generations of Multiracial Americans. To narrow this research gap, this study investigated the prevalence/frequency of substance use and major depressive episodes [MDE] among non-Hispanic Multiracial [NHM] adolescents compared to their non-Hispanic White [NHW] counterparts and whether racial differences vary by socioeconomic status.
Methods: We analyzed data from the 2015-2019 National Survey on Drug Use and Health (N = 3,645 NHM and 34,776 NHW adolescents aged 12-17).