Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate.

The rapid emergence and spread of multidrug-resistant bacterial pathogens require the development of antibacterial agents that are robustly effective while inducing no toxicity or resistance development. In this context, we designed and synthesized amphiphilic dendrimers as antibacterial candidates. We report the promising potent antibacterial activity shown by the amphiphilic dendrimer , composed of a long hydrophobic alkyl chain and a tertiary amine-terminated poly(amidoamine) dendron, against a panel of Gram-negative bacteria, including multidrug-resistant and exhibited effective activity against drug-resistant bacterial infections in vivo.

Xylan-Porphyrin Hydrogels as Light-Triggered Gram-Positive Antibacterial Agents.

In the present work, we report on the synthesis of light-triggered antibacterial hydrogels, based on xylan chains covalently bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). Not only does TCPP act as a photosensitizer efficient against Gram-positive bacteria, but it also serves as a cross-linking gelator, enabling the simple and easy building of xylan conjugate hydrogels. The hydrogels were characterized by infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), along with swelling and rheological tests.

Xylan-Based Cross-Linked Hydrogel for Photodynamic Antimicrobial Chemotherapy.

Photodynamic antimicrobial chemotherapy or PACT has been shown to be a promising antibacterial treatment that could overcome the challenge of multidrug-resistant bacteria. However, the use of most existing photosensitizers has been severely hampered by their significant self-quenching effect, poor water solubility, lack of selectivity against bacterial cells, and possible damage to the surrounding tissues. The use of hydrogels may overcome some of these limitations.

Evaluation of chemometric techniques to select orthogonal chromatographic systems.

Several chemometric techniques were compared for their performance to determine the orthogonality and similarity between chromatographic systems. Pearson's correlation coefficient (r) based color maps earlier were used to indicate selectivity differences between systems. These maps, in which the systems were ranked according to decreasing or increasing dissimilarities observed in the weighted-average-linkage dendrogram, were now applied as reference method.