Publications by authors named "A El-Solh"
Article Synopsis
- Traditional treatments for obstructive sleep apnea (OSA) mainly focus on methods like continuous positive airway pressure therapy and oral appliances, but they don't tackle the underlying metabolic issues that contribute to the condition.
- Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially created for managing type 2 diabetes, show promise in helping obese patients with OSA by promoting significant weight loss and reducing fat around the airway.
- Emerging research indicates that integrating GLP-1 RAs into standard OSA treatments could improve patient outcomes by addressing both obesity and related health issues, potentially changing the way OSA is managed in the future.
Bacteriology of Aspiration Pneumonia: The Lung Microbiome and the Changing Microbial Etiology.
Semin Respir Crit Care Med
December 2024
Aspiration pneumonia refers to the process of alveolar inflammation induced by the inhalation of oropharyngeal secretions into the lower respiratory tract. Predisposing factors comprise swallowing dysfunction, impaired cough reflex, and degenerative neurological diseases. Accumulating evidence projects a fading contribution of anaerobic bacteria in aspiration pneumonia at the expense of Gram-negative bacilli, with , , and , becoming the predominant organisms recovered from respiratory specimens.
View Article and Find Full Text PDFTreatment of insomnia associated with alcohol and opioid use: a narrative review.
Sleep Biol Rhythms
October 2024
Substance use disorders (SUDs) are associated with profound sleep disturbances, including insomnia, sleep fragmentation, and circadian rhythm dysfunction resulting in serious mental and physical consequences. This minireview presents an overview of the neurocircuitry underlying sleep disturbances in SUDs and elaborates on treatment options with emphasis on alcohol use disorder (AUD) and opioid use disorder (OUD). A PubMed, Embase, CINAHL Plus, Cochrane, and Scopus search were conducted using sleep- and AUD/OUD related keywords from January 1st, 2000, to January 31st, 2023, with preferences for recent publications and randomized-controlled trials.
View Article and Find Full Text PDFExisting evidence linking insomnia to all-cause mortality in older individuals remains inconclusive. We conducted a retrospective study of a large cohort of veterans aged 65-80 years old identified from the Corporate Data Warehouse, a large data repository derived from the Veterans Health Administration integrated medical records. Veterans' enrollees with and without International Classification of Diseases, Ninth and Tenth Revision, codes corresponding to insomnia diagnosis between 1 January 2010 and 30 March 2019 were assessed for eligibility.
View Article and Find Full Text PDFAssociation Between Hypnotic Use and All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease and Insomnia.
Int J Chron Obstruct Pulmon Dis
November 2023
Purpose: Hypnotics are commonly prescribed in patients with COPD to manage insomnia. Given the considerable risks associated with these drugs, the aim of the study was to evaluate the risk of all-cause mortality associated with hypnotics in a cohort of veterans with COPD presenting with insomnia.
Methods: We conducted a retrospective cohort study that used Veterans Health Administration Corporate Data Warehouse with data supplemented by linkage to Medicare, Medicaid, and National Death Index data from 2010 through 2019.