Publications by authors named "A El-Kersh"
Background: Ageing is a key risk factor for cardiovascular disease and is linked to several alterations in cardiac structure and function, including left ventricular hypertrophy and increased cardiomyocyte volume, as well as a decline in the number of cardiomyocytes and ventricular dysfunction, emphasizing the pathological impacts of cardiomyocyte ageing. Dental pulp stem cells (DPSCs) are promising as a cellular therapeutic source due to their minimally invasive surgical approach and remarkable proliferative ability.
Aim: This study is the first to investigate the outcomes of the systemic transplantation of DPSCs in a D-galactose (D-gal)-induced rat model of cardiac ageing.
Article Synopsis
- * After hDPSCs were injected into diabetic rats, results showed improved blood glucose levels, enhanced parotid gland function, and decreased oxidative stress.
- * hDPSCs were found to migrate to the damaged glands and differentiate into various cell types, while also regulating important growth factors related to tissue repair.
Background: The choice of ring type for mitral valve (MV) repair is still debatable and usually is left to the surgeon's discretion.
Aim: The aim of this study was to compare the early and mid-term results after repair of ischaemic mitral regurgitation (MR) with complete and incomplete annuloplasty rings.
Methods: Collected data included preoperative assessment (age, sex, comorbidities, clinical status, NYHA grade, and the EURO score); intraoperative details (echocardiography, degree of MR, and cross-clamp time); and results (the length of ICU and hospital stay, duration and need for inotropes, duration of mechanical ventilation, and postoperative adverse events).
Article Synopsis
- Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells, prompting research into therapies using human dental pulp stem cells due to their accessibility and ability to proliferate.
- A study evaluated the effects of transplanting these stem cells in a rat model of T1DM, comparing intravenous and intrapancreatic injections, with both methods showing potential in reducing blood glucose levels and increasing insulin and C-peptide.
- Findings indicated the stem cells engrafted in the pancreas, forming insulin-expressing clusters and displaying gene expression associated with pancreatic β-cells, highlighting their therapeutic viability for diabetes.
Background: Egypt is the most populous country in the Middle East and North Africa and has more than 15% of the cardiovascular deaths in the region, but little is known about the prevalence of traditional risk factors and treatment strategies in acute coronary syndrome (ACS) patients across Egypt.
Methods: From November 2015 to August 2017, data were collected from 1 681 patients with ACS in 30 coronary care centres, covering 11 governorates across Egypt, spanning the Mediterranean coast, Nile Delta and Upper Egypt, with a focus on risk factors and management strategies.
Results: Women constituted 25% of the patients.