Publications by authors named "A Eckhardt"
Background: Ependymomas of the spinal cord are rare among children and adolescents, and the individual risk of disease progression is difficult to predict. This study aims to evaluate the prognostic impact of molecular typing on pediatric spinal cord ependymomas.
Methods: Eighty-three patients with spinal ependymomas ≤22 years registered in the HIT-MED database (German brain tumor registry for children, adolescents, and adults with medulloblastoma, ependymoma, pineoblastoma, and CNS-primitive neuroectodermal tumors) between 1992 and 2022 were included.
Pulmonary hypertension is a complex and heterogeneous condition with five main subtypes (groups). This review focuses on pulmonary hypertension caused by chronic hypoxia (hypoxic pulmonary hypertension, HPH, group 3). It is based mainly on our own experimental work, especially our collaboration with the group of Professor Herget, whose fifth anniversary of death we commemorate.
View Article and Find Full Text PDFBackground: The Chest Pain Conception Questionnaire was developed to measure the lay public's conceptions of chest pain related to acute coronary syndrome.
Objective: The purpose of this study was to further test the Chest Pain Conception Questionnaire in a racially and ethnically diverse sample.
Methods: Participants from across the United States completed an online survey.
Article Synopsis
- - H3 K27M-altered diffuse midline gliomas (DMGs) are aggressive brain tumors that mostly have a specific mutation in the histone H3 gene and can be categorized into subgroups based on various traits like mutation types and tumor locations.
- - Researchers analyzed 149 DMGs, looking into their DNA methylation patterns and found two main subtypes: DMG-A and DMG-B, which differ in mutation profiles, tumor locations, patient age, and overall survival rates.
- - DMG-A, primarily affecting adults and often located in the medulla, showed better survival rates compared to DMG-B, which is more common in children and associated with poorer outcomes; subtype classification based on methylation patterns
Fibrotic changes in pediatric clubfoot provide an opportunity to improve corrective therapy and prevent relapses with targeted drugs. This study defines the parameters of clubfoot fibrosis and presents a unique analysis of a simple pseudo-3D model for disease-specific high-throughput drug screening experiments. The model combines clubfoot-derived fibroblasts with a biomimetic cultivation environment induced by the water-soluble polymers Ficoll and Polyvinylpyrrolidone, utilizing the principle of macromolecular crowding.
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