Use and misuse of domperidone in patients living with Parkinson disease in France.

Context: After observing increased sudden death risk associated with domperidone use, the European Medicines Agency (EMA) imposed usage restrictions in 2014, limiting age (≤60 years), daily dose (≤30 mg/day), and duration (≤7 days). Nausea commonly occurs as an adverse effect of dopaminergic drugs in Parkinson's disease (PD) patients, with few alternative anti-emetic options. This study aimed to assess domperidone prescription patterns in French PD patients.

Developing a training for 3D transrectal multiparametric ultrasound of the prostate: a human factors engineering approach.

Objective: Three-dimensional multiparametric ultrasound (3D mpUS) shows promise for accurately diagnosing prostate cancer. However, its technical complexity presents usability challenges. Human Factor Engineering (HFE) studies the interaction between devices and users, by reducing human error, increasing productivity, and enhancing safety.

Environmental Impact Assessment of Intravenous Versus Subcutaneous Monoclonal Antibodies: A Carbon Footprint Analysis.

Purpose: The development of subcutaneous (SC) formulations for monoclonal antibodies (mAbs), as an alternative to conventional intravenous (IV) infusion, represents a shift in health care delivery. The relative environmental impact of these two administration methods is not well understood. Minimizing the environmental footprint of health care is crucial due to its substantial contribution to greenhouse gas (GHG) emissions.

A dataset for monitoring agricultural drought in Europe.

This paper introduces the Combined Drought Indicator dataset, a collection of raster maps generated by the Copernicus European Drought Observatory for monitoring agricultural drought in Europe. Computationally, the CDI involves three indicators: the Standardized Precipitation Index, the Soil Moisture Anomaly and the Fraction of the Photosyntetically Active Radiation anomaly. These are complemented by the use of crop and snow masks.

Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL.

Relapse continues to limit survival for patients with B-cell acute lymphoblastic leukemia (B-ALL). Previous studies have independently implicated activation of B-cell developmental signaling pathways and increased glucose consumption with chemo-resistance and relapse risk. Here, we connect these observations, demonstrating that B-ALL cells with active signaling, defined by high expression of phosphorylated ribosomal protein S6 ("pS6+ cells"), are metabolically unique and glucose dependent.