Results of Concurrent Patch Testing of Brazilian and Chinese Propolis.

Background: In Amsterdam, a steep increase in positive reactions to propolis in the European baseline series was observed from 2.8% in 2020 to 16.4% in 2023.

Parasitism as a potential driver of aposematism.

Aposematic animals couple unprofitability to predators, such as toxicity, with a warning signal, such as conspicuous coloration. Although toxicity and coloration can provide effective protection against predation, these traits also play a major role in the context of parasitism. Many of the color pigments used by aposematic animals are components of anti-infection immunity.

CBX7 inhibitors affect H3K9 methyltransferase-regulated gene repression in leukemic cells.

The epigenome of leukemic cells is dysregulated, and genes required for cell cycle arrest and differentiation may become repressed, which contributes to the accumulation of undifferentiated malignant blood cells. Here, we show that the Polycomb group protein CBX7 can interact with H3K9 methyltransferases EHMT1/2 and SETDB1. We aimed to assess whether combined interfering with these H3K9 methyltransferases and CBX7 could derepress target genes and thereby induce growth arrest of leukemic cells.

Safety Assessment of Butyric Acid-Rich Triglyceride Oil: A Novel Palatable Formulation of Butyrate for the Pediatric Population.

A novel, palatable butyric acid-rich triglyceride oil has been developed and is available as a food supplement for adults in the United States and Canada. A program of safety studies was conducted with butyric acid-rich triglyceride oil for the pediatric population. The oil was tested in a microbial reverse mutation assay Ames Test OECD471 (Organisation for Economic Co-operation and Development) in which all bacterial strains showed negative responses over the complete dose range in two independently repeated experiments.

Collaborative working with Parents of Children with DLD in Speech and Language Therapy: Identifying Dutch Speech and Language Therapists' barriers to enhancing practice.

Background: Collaboration between Speech and Language Therapists (SLTs) and parents is considered best practice for children with developmental disorders. However, such collaborative approach is not yet implemented in therapy for children with developmental language disorders (DLD) in the Netherlands. Improving Dutch SLTs' collaboration with parents requires insight in factors that influence the way SLTs work with parents.