CXCR4 Is a Potential Target for Anti-HIV Gene Therapy.

The human immunodeficiency virus (HIV) epidemic is a global issue. The estimated number of people with HIV is 39,000,000 to date. Antiviral therapy is the primary approach to treat the infection.

Association between coping resources and mental health during the COVID-19 pandemic: a cross-sectional study in the Czech Republic.

The COVID-19 pandemic has caused detrimental global consequences for public health, health-care systems, economies, and society in general. The Czech Republic was one of the most affected countries in the world regarding daily cases increases during the first waves of the pandemic. The present study investigates the association between coping resources, mental health and anxiety.

[Lack of GAGA protein in Trl mutants causes massive cell death in Drosophila spermatogenesis and oogenesis].

Drosophila protein GAGA (GAF) is a factor of epigenetic transcription regulation of a large group of genes with a wide variety of cellular functions. GAF is encoded by the Trithorax-like (Trl) gene, which is important for the formation of various organs and tissues at all stages of ontogenesis. In our previous works, we showed that this protein is necessary for the development of the reproductive system, both in males and females of Drosophila.

On proportional deformation paths in hypoplasticity.

We investigate rate-independent stress paths under constant rate of strain within the hypoplasticity theory of Kolymbas type. For a particular simplified hypoplastic constitutive model, the exact solution of the corresponding system of nonlinear ordinary differential equations is obtained in analytical form. On its basis, the behaviour of stress paths is examined in dependence of the direction of the proportional strain paths and material parameters of the model.