Publications by authors named "A E Zakharov"
SARS-CoV-2 infections led to a worldwide pandemic in 2020. As of 2024, therapeutics against SARS-CoV-2 have continued to be desirable. NSP14 is a dual-function methyltransferase (MTase) and exonuclease (ExoN) with key roles in SARS-CoV-2 genome propagation and host immune system evasion.
View Article and Find Full Text PDFPair correlations for a polar liquid-crystal (LC) system have been theoretically investigated by means of integral equation approach. Using the dipolar Gay-Berne (GB) interactions between the molecules that composed the LC system, calculations of the nearest-neighbor (NN) and next-NN (NNN) correlators as well as the order parameters and the static dielectric coefficients were performed. It is shown that for a simple cubic packing, NN dipoles tend to be mutually antiparallel with respect to the central dipole, while the opposite trend was observed for NNN dipoles.
View Article and Find Full Text PDFNanoscale detection and control of the magnetic order underpins a spectrum of condensed-matter research and device functionalities involving magnetism. The key principle involved is the breaking of time-reversal symmetry, which in ferromagnets is generated by an internal magnetization. However, the presence of a net magnetization limits device scalability and compatibility with phases, such as superconductors and topological insulators.
View Article and Find Full Text PDFArticle Synopsis
- Hyperhomocysteinemia (hHCY) is linked to increased plasma homocysteine levels and correlates with a higher risk of migraines, especially those with aura.
- The study investigated how hHCY affects cortical spreading depression (CSD) and neuronal activity in the somatosensory cortex of rats, highlighting an increased excitability and more frequent CSDs in those with hHCY.
- Results showed impaired CSD propagation and delayed recovery of brain activity in hHCY animals, indicating that prolonged high homocysteine levels may increase the risk of migraine-associated brain injuries.
[Validation of ballistocardiography data for predicting the sleep efficiency in healthy individuals and patients with insomnia].
Zh Nevrol Psikhiatr Im S S Korsakova
November 2024
Objective: To identify valid parameters of heart rate variability (HRV) and musculoskeletal movements based on ballistocardiography data, which allow predicting the sleep efficiency (SE) index in healthy individuals and patients with insomnia.
Material And Methods: Ten healthy individuals and 14 patients with chronic insomnia were examined using polysomnography and ballistocardiography. A regression analysis of the data was carried out, as well as a reliability check of the resulting mathematical model.