Publications by authors named "A E Yuzhalin"
Article Synopsis
- Advanced pancreatic ductal adenocarcinomas (PDACs) have a poor response to all existing therapies, making effective treatment a significant challenge for patients with late-stage disease.
- Researchers discovered a new chemo-induced signaling network that contributes to chemoresistance in PDAC, highlighting Yap1 in cancer cells and Cox2 in stromal fibroblasts as critical components.
- Co-targeting both Yap1 and Cox2 markedly increased the effectiveness of Gemcitabine treatment in mice, and patient data suggested that combining statins and Cox2 inhibitors with Gemcitabine could enhance survival rates for PDAC patients.
Background: Citrullination represents a post-translational modification primarily mediated by peptidylarginine deiminase (PADI) 2 and 4 and resulting in the conversion of positively charged peptidylarginine to neutrally charged peptidylcitrulline. Molecular consequences of citrullination include the generation of neoepitopes which provoke the production of autoantibodies implicated in the development of autoimmune diseases. As citrullination initiates, promotes, and is enhanced by aseptic inflammation which plays a pivotal role in atherosclerosis, we proposed that citrullination might accompany the development of atherosclerotic vascular disease.
View Article and Find Full Text PDFArticle Synopsis
- Brain metastases (BrMs) evade the immune system by overexpressing Cdk5, which helps them grow in the brain while reducing MHC-I expression and function, important for T cell recognition.
- * By inhibiting Cdk5, researchers can restore MHC-I levels and improve immune response against these tumors, as shown through various studies including RNA sequencing.
- * Treatment with the Cdk5 inhibitor roscovitine, especially when combined with immune checkpoint inhibitors, reduces BrM growth and enhances the presence of functional CD8 T cells in mice.
Cancer research has played a pivotal role in improving patient outcomes. However, despite the significant investment in fundamental cancer research over the past few decades, the translation of funding into substantial advancements in cancer treatment has been limited. This perspective article employs a detailed analysis to outline strategies for promoting innovation and facilitating discoveries within the field of cancer research.
View Article and Find Full Text PDFCritical functions of extracellular matrix in brain metastasis seeding.
Cell Mol Life Sci
September 2023
Human brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both physiological and pathological conditions should not be underestimated. Brain metastasis is a serious complication of cancer, and recent findings highlighted the contribution of ECM in brain metastasis development.
View Article and Find Full Text PDF