Publications by authors named "A E Yeager"
Article Synopsis
- The human MRGPRD protein is part of a family of receptors that play a key role in detecting pain and itch, but it's not well-researched and has few known activating compounds.
- The study identifies two new potent agonists, EP-2825 and EP-3945, that are about 100 times more effective than the previously known agonist, β-alanine.
- The researchers also explored the structures of MRGPRD bound to these agonists, revealing unique binding interactions and flexibility in the receptor, which could help in creating new drugs targeting MRGPRD.
Article Synopsis
- Novel technologies like ecological momentary assessment (EMA) and wearable biosensors are being explored to improve psychological treatment outcomes, though their feasibility and reliability are still unclear.
- * The study involved 20 adults with borderline personality disorder who participated in dialectical behavior therapy, utilizing EMA and biosensors to evaluate emotion regulation and emotional states over six months.
- * Results indicated moderate participant engagement with EMA but no significant correlation between emotional states measured through EMA and electrodermal activity; smaller changes in negative affect were linked to higher suicidal thinking ratings over time.
Innovations in Preconception Care: Optimizing Health for All Individuals.
J Midwifery Womens Health
December 2024
Optimizing the overall health of individuals prior to pregnancy can improve both pregnancy and lifelong health outcomes. Despite extremely high financial expenditure on birth in the United States, maternal and infant mortality rates continue to rise. Moreover, significant racial and ethnic disparities persist in perinatal health outcomes.
View Article and Find Full Text PDFBackground: DNA polymerase theta (POLQ) is an enzyme that repairs double-strand DNA breaks. POLQ is overexpressed in several cancer types, and increased expression is associated with a poor prognosis. Ablating POLQ function in vitro increases drug sensitivity to agents that cause double-strand DNA breaks, including chemotherapies and ionizing radiation.
View Article and Find Full Text PDFBackground: The Reducing Disability in Alzheimer's Disease in Kansas City (RDAD-KC) intervention has been shown to improve the health of individuals with dementia and caregiver dyads. This manuscript reports the results of implementing the RDAD among individuals with intellectual disabilities and caregiver dyads.
Methods: Nine community agencies deployed the 12-week intervention.