Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung.

Bacteremia, a leading cause of death, generally arises after bacteria establish infection in a particular tissue and transit to secondary sites. Studying dissemination from primary sites by solely measuring bacterial burdens does not capture the movement of individual clones. By barcoding Klebsiella pneumoniae, a leading cause of bacteremia, we track pathogen dissemination following pneumonia.

Navigating ethics in HIV data and biomaterial management within Black, African, and Caribbean communities in Canada.

Background: This study explored the ethical issues associated with community-based HIV testing among African, Caribbean, and Black (ACB) populations in Canada, focusing on their perceptions of consent, privacy, and the management of HIV-related data and bio-samples.

Methods: A qualitative community-based participatory research (CBPR) approach was employed to actively engage ACB community members in shaping the research process. The design included in-depth qualitative interviews with 33 ACB community members in Manitoba, Canada.

SARS-CoV-2 Omicron variations reveal mechanisms controlling cell entry dynamics and antibody neutralization.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is adapting to continuous presence in humans. Transitions to endemic infection patterns are associated with changes in the spike (S) proteins that direct virus-cell entry. These changes generate antigenic drift and thereby allow virus maintenance in the face of prevalent human antiviral antibodies.

Single breath-hold volumetric lung imaging at 0.55T using stack-of-spiral (SoS) out-in balanced SSFP.

Purpose: To develop a robust single breath-hold approach for volumetric lung imaging at 0.55T.

Method: A balanced-SSFP (bSSFP) pulse sequence with 3D stack-of-spiral (SoS) out-in trajectory for volumetric lung imaging at 0.

Early-life menstrual characteristics and gestational diabetes in a large US cohort.

Background: Associations between early-life menstrual cycle characteristics (MCC) and gestational diabetes (GDM) remain unclear.

Objectives: To evaluate associations between early-life MCCs and GDM in first pregnancy, across pregnancies and its recurrence.

Methods: This analysis included participants from a US-based digital cohort enrolled between 11/2019 and 9/2023 who provided consent, completed relevant surveys, were without diabetes and aged ≥18 at first pregnancy (n = 30,473).