Publications by authors named "A E WASSERMAN"
Article Synopsis
- The study investigates how social and home environments influence early substance use initiation (SUI) in adolescents, particularly focusing on alcohol (AUI) and cannabis (CUI) use.
- It examines whether family history of substance use disorders (FH+) affects the relationship between these environmental factors and SUI.
- Findings reveal that risky peer affiliations increase the risk of AUI and CUI regardless of FH status, but a strong mother-youth relationship can provide protection from CUI, which is weakened for those with a FH+.
Since the SARS-CoV-2 outbreak, there have been ongoing efforts to identify antiviral molecules with broad coronavirus activity to combat COVID-19. SARS-CoV-2's main protease (M) is responsible for processing the viral polypeptide into non-structural proteins essential for replication. Here, we present the biological characterization of AB-343, a covalent small-molecule inhibitor of SARS-CoV-2 M with potent activity in both cell-based (EC = 0.
View Article and Find Full Text PDFBackground: Proton pump inhibitors (PPIs) are often prescribed to manage corticosteroid-induced gastrointestinal toxicity during glioblastoma (GBM) treatment, but were recently identified as strong inducers of aldehyde dehydrogenase-1A1 (ALDH1A1). ALDH1A1 is a primary metabolic enzyme impacting the outcome of chemotherapy, including temozolomide. High expression of ALDH1A1 is associated with poor prognosis in multiple cancers, suggesting PPIs may have a negative impact on survival.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze C-reactive protein (CRP) levels in patients with different types of infections, including viral infections and bacteremia, to understand how CRP behaves during acute infections.
- Using electronic medical records, the researchers tracked CRP levels in hospitalized patients and found that the patterns of CRP varied depending on the infection type and whether patients received antibiotic treatment.
- Results showed that viral infections had lower CRP levels, while Gram-negative bacteremia had the highest peaks, indicating that monitoring CRP could help with diagnosis and assessing risk in hospitalized patients.
Importance: The conditions required for health record data sources to accurately assess treatment effectiveness remain unclear. Emulation of randomized clinical trials (RCTs) with health record data and subsequent calibration of the results can help elucidate this.
Objective: To pilot an emulation of the KEYNOTE-189 RCT using a commercially available electronic health record (EHR) data source.