Line-field confocal optical coherence tomography (LC-OCT) is a novel imaging technique for in vivo examination of the skin that has recently been introduced in the dermatologic armamentarium of non-invasive diagnostic tools. Its usefulness in the diagnosis and treatment monitoring of some neoplastic, inflammatory, and infectious skin conditions has been demonstrated. The aim of this study was to evaluate the LC-OCT features of psoriasis in a large number of psoriatic plaques along with their histopathologic correlation.
View Article and Find Full Text PDFA 72-year-old man presented with actinic keratosis (AK) of the scalp confirmed by line-field confocal optical coherence tomography (LC-OCT) a novel non-invasive skin imaging technique. Patient was treated with Tirbanibulin 1% ointment once a day for 5 consecutive days and, after 8 days from baseline, mild erythema and desquamation was observed on the treated area, associated with mild pruritus. At the same time-point, L'LC-OCT revealed the presence of intraepidermal "targeted-like" cells, corresponding to apoptotic keratinocytes.
View Article and Find Full Text PDFObjective: To examine the impact of fluocinonide 0.05% gel formulation for the topical treatment of oral lichen planus (OLP).
Methods: Through an RCT design, 47 patients with OLP were randomly allocated for topical OLP treatment with fluocinonide 0.
Background: Line-field confocal optical coherence tomography is a novel technology able to reproduce a "virtual biopsy" of the skin. The aim of this review is to explore the application of line-field confocal optical coherence tomography (LC-OCT) in various skin diseases, covering skin cancers, inflammatory and infectious skin diseases, genetic diseases, cosmetic procedures, and less common disorders.
Methods: Study selection was conducted based on LC-OCT and using pertinent MeSh terms, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines from inception to March 2024; to evaluate the quality and risk of bias of studies, Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used.