Colistin- and carbapenem-resistant (ColR CrKp) cause important health problems in pediatric intensive care units (PICUs) due to its ability to harbor multiple resistance genes and spread of high-risk clones. In this study, molecular epidemiological characteristics, transferable resistance genes, and alterations of ColR CrKp isolated from PICU were investigated. Isolates were identified by MALDI-TOF MS, and antimicrobial susceptibility tests were performed using disk diffusion method, gradient strip test, and broth microdilution method.
View Article and Find Full Text PDFObjectives: In this investigation, the protective effects of hydroxytyrosol (HT) administered prior to myocardial infarction in rats were examined, with a particular focus on its potential roles within the Notch pathway.
Materials And Methods: The animals were categorized into seven groups (n=7): control, myocardial infarction (MI) 6 hr, MI 24 hr, MI 7 day, MI+HT 6 hr, MI+HT 24 hr, MI+HT 7 day. In order to create infarction, the rats received a subcutaneous injection of isoproterenol at a dose of 200 mg/kg.
Phytochemical investigation of the roots of yielded a new phenylpropanoid, adenophoride () and a new polyacetylene, adenylene () along with four phenylpropanoids and a polyacetylene. The structures were determined by spectroscopic analysis including NMR, MS, UV and IR. Among the isolated compounds, phenylpropanoids including a new compound showed mild α-glucosidase inhibitory activities.
View Article and Find Full Text PDFBackground: There is a lack of evidence regarding the effect of combining arm and leg training on arm exercise capacity, upper extremity functionality and safety in patients with implantable cardioverter-defibrillators (ICDs).
Objective: The aim of this study was to compare the effects of combined arm-leg endurance training (ET) with leg endurance training (ET) alone on arm exercise capacity, cardiorespiratory fitness, and safety issues in patients with ICDs.
Methods: In this prospective randomized controlled study, 24 caucasian patients with an ICD (NYHA class II-III, mean age: 59.