A Photographic Case of Frostbite Treated with Delayed Hyperbaric Oxygen Therapy.

Davis, Ashlee, Brent Sinopoli, Nathaniel Mann, and Antine E. Stenbit. A photographic case of frostbite treated with delayed hyperbaric oxygen therapy.

Efficacy of therapeutic plasma exchange in the treatment of penn class 3 and 4 cytokine release syndrome complicating COVID-19.

Objectives: Cytokine release syndrome (CRS) is a potentially severe complication of COVID-19 most commonly resulting in respiratory failure. This ten-patient study was designed to determine the efficacy of therapeutic plasma exchange (TPE) in improving oxygenation and in reducing the cytokine load in a critically ill subset of patients.

Methods: Five single volume plasma exchanges over eight days within a 14-day study period.

Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways.

The mechanisms for the development of bronchiectasis and airway hyperreactivity have not been fully elucidated. Although genetic, acquired diseases and environmental influences may play a role, it is also possible that motile cilia can influence this disease process. We hypothesized that deletion of a key intraflagellar transport molecule, IFT88, in mature mice causes loss of cilia, resulting in airway remodeling.

Timing of inhaled tobramycin affects assessment of intravenous tobramycin pharmacokinetic monitoring.

Background: Aerosolized tobramycin inhalation solution (TIS) may be absorbed and result in measurable serum concentrations. We assessed the significance of TIS dosing in the latter portion of the IV dosing interval on the calculation of pharmacokinetic (PK) parameters and dosing.

Methods: Twenty adult CF patients admitted to the hospital for treatment of a pulmonary exacerbation were enrolled.