Publications by authors named "A E Steimle"
Article Synopsis
- Gut bacteria are connected to neurodegenerative diseases, but understanding their role is limited due to the complexities beyond just microbiota composition.
- In a study using a mouse model for multiple sclerosis, researchers tested various genotypes and microbiota combinations to see how they affected neuroinflammation severity.
- They found that while certain bacteria like Akkermansia muciniphila are linked to MS, other factors like individual immune responses and the overall microbial community play a crucial role in predicting disease severity.
Article Synopsis
- Inflammatory bowel disease (IBD) affects the intestines and is caused by a mix of genes and environment, but not everything is fully understood.
- Scientists found that some mice were better at fighting this disease because of special bacteria in their guts that help protect their intestines.
- By studying these bacteria, researchers learned they can help improve gut health, which could lead to new treatments for IBD in people.
Background: The mycotoxin deoxynivalenol (DON) is a frequent contaminant of grain and cereal products worldwide. Exposure to DON can cause gastrointestinal inflammation, disturb gut barrier function, and induce gut dysbiosis in vivo under basal conditions, but little is known about the effects of DON ingestion in individuals with pre-existing gastrointestinal disease.
Objectives: Mice were orally exposed to 10 and 100 μg/kg bw/day of DON, corresponding to 10 to 100-fold human tolerable daily intake concentrations, and to the translation in mice of current human daily intake.
The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic polymorphisms, infections and smoking, environmental triggers have been considered. Recent sequencing-based approaches have revealed that patients with extra-intestinal ADs, such as multiple sclerosis, rheumatoid arthritis, type 1 diabetes and systemic lupus erythematosus, have distinct gut microbiota compositions compared to healthy controls.
View Article and Find Full Text PDFFood safety has considerably improved worldwide, yet infections with foodborne human enteric pathogens, such as spp. and Salmonella spp., still cause numerous hospitalizations and fatalities.
View Article and Find Full Text PDF