[Photodynamic therapy of prostatic adenoma].

We were the first to study feasibility of photodynamic therapy (PDT) for prostatic adenoma using photosensitizer from chlorine group--photoditasine. We have developed and used PDT technique with application of 3-way silicon catheter with two balloons. This allows care for presenile and senile patients with compromised somatic status who are at high surgical risk of standard operations.

[Fluorescence detection of chlorine E6 based photosensitizer in urinary bladder tumors].

The authors present pilot experience with accumulation and distribution of chlorine E6 based photosensitizer in unaffected mucosa and tumor of human urinary bladder (UB). Local fluorescence spectroscopy in vivo has shown that 2-3 hours after intravenous injection of the photosensitizer in a dose 1 mg/kg its exogenic fluorescence is detected in the tumor but not in unaffected UB mucosa. This indicates selective accumulation of the sensitizer in UB tumors.

[Photodynamic therapy of urinary bladder cancer using a chlorin based photosensitizer].

Photodynamic therapy (PDT) is a modem, low-invasive method of urinary bladder (UB) cancer treatment. PDT can induce complete or partial destruction of the tumor, reduce recurrence rate, provide assistance to elderly patients with compromised somatic status who are not radically operable. A combined technique improves the results of photodynamic therapy in patients with surface and invasive UB cancer of stage T2 because photodynamic impact affects not only the tumor but also all UB mucosa by light fiber with cylindric diffusor introduced in a silicon balloon with water.

[Fluorescence detection of photosensitizer photoditazin in the tissue of benign prostatic hyperplasia].

The authors present pilot experience in investigation of accumulation, distribution and elimination of photosensitizer photoditazin from hyperplastic tissue of human prostate. Fluorescent spectroscopy showed that 2-24 hours after intravenous injection of photoditazin in a dose 1 mg/kg, it is detected in hyperplastic tissue of human prostate with maximal accumulation 3 hours after introduction. Exogenic fluorescence of photoditazin lowered 12 and 24 hours after injection this indicating its elimination.