Publications by authors named "A E Sloan"
Background: Venous thromboembolisms (VTE's) are the second leading cause of death in cancer patients. While previous analyses have demonstrated VTE rates are greater in GBM patients using smaller patient cohorts in high-grade glioma, since the release of the update 5 edition of the World Health Organization (WHO) classification a systematic analysis in a large-scale cohort of patients with IDH-wildtype GBM with clinical outcomes is lacking.
Methods: This study utilizes the online database, TriNetx, to build patient cohorts for outcomes analysis.
Background: Dermatomyositis is a chronic autoimmune disease with distinctive cutaneous eruptions and muscle weakness, and the pathophysiology is characterised by type I interferon (IFN) dysregulation. This study aims to assess the efficacy, safety, and target engagement of dazukibart, a potent, selective, humanised IgG1 neutralising monoclonal antibody directed against IFNβ, in adults with moderate-to-severe dermatomyositis.
Methods: This multicentre, double-blind, randomised, placebo-controlled, phase 2 trial was conducted at 25 university-based hospitals and outpatient sites in Germany, Hungary, Poland, Spain, and the USA.
Background: Meningiomas exhibit considerable clinical and biological heterogeneity. We previously identified four distinct molecular groups (immunogenic, NF2-wildtype, hypermetabolic, proliferative) that address much of this heterogeneity. Despite the utility of these groups, the stochasticity of clustering methods and the use of multi-omics data for discovery limits the potential for classifying prospective cases.
View Article and Find Full Text PDFObjectives: To identify evidence and guidelines relating to the use of antibiotics in the management of odontogenic facial swellings in children and adolescents.
Data: Articles relating to odontogenic facial swellings in children and adolescents aged 0-16 years were included. Articles in which paediatric data could not be differentiated from adult data or where the age of participants were unknown were excluded.
Article Synopsis
- Autoerotic asphyxial deaths, primarily involving neck compression, are rare but notable, with a study analyzing 72 cases in Australia from 2000 to 2022 to understand their medical and legal implications.
- The demographic findings highlighted a tendency for victims to be Caucasian males under 50, while the study discovered a range of injuries, including both minor and severe, alongside consistent evidence of sexual paraphernalia and isolation in these cases.
- The researchers advocate for better categorization of autoerotic neck compression deaths to differentiate them from suicidal and homicidal cases, emphasizing the need for incorporating new variables in future investigations.