Publications by authors named "A E Shulga"
Article Synopsis
- A new technique called high-PAS combines high-frequency peripheral nerve stimulation (PNS) and high-intensity transcranial magnetic stimulation (TMS) to potentially enhance motor function in patients with incomplete spinal cord injuries.
- The interstimulus interval (ISI) in high-PAS allows for flexibility, making it easier to implement in clinical settings where precise timing is tough, but this also creates challenges for measuring its effectiveness.
- Research with ten healthy participants showed that high-PAS improved motor-evoked potentials (MEPs) and significantly increased spinal excitability (measured by H-reflex amplitudes) during spinal-targeted sessions, but not in cortical-targeted sessions.
Article Synopsis
- Paired associative stimulation (PAS) combines transcranial magnetic stimulation (TMS) and peripheral nerve stimulation (PNS) to enhance motor-evoked potentials (MEPs) and promote spinal plasticity, particularly beneficial for rehabilitation after spinal cord injury (SCI).
- A new high-frequency variant of PAS, called "high-PAS," was tested alongside noninvasive auricular vagus nerve stimulation (aVNS) to see if it could further boost MEP enhancement.
- While PAS significantly improved MEPs compared to aVNS alone, the combined effects did not yield significant results, indicating that more optimization of the aVNS setup is needed for potential use in SCI patients.
Anatomic visualization and molecular typing of metastatic regional lymph nodes in breast cancer patients are a serious clinical challenge in modern oncology. According to the results of previous studies, [99mTc]Tc-(HE)3-G3 has proven to be a promising diagnostic agent in differentiating the HER2/neu receptor status in primary breast tumors ( < 0.05, Mann-Whitney test).
View Article and Find Full Text PDFPaired associative stimulation (PAS) consisting of high-intensity transcranial magnetic stimulation (TMS) and high-frequency peripheral nerve stimulation (known as high-PAS) induces plastic changes and improves motor performance in patients with incomplete spinal cord injury (SCI). Listening to music during PAS may potentially improve mood and arousal and facilitate PAS-induced neuroplasticity via auditory-motor coupling, but the effects have not been explored. This pilot study aimed to determine if the effect of high-PAS on motor-evoked potentials (MEPs) and subjective alertness can be augmented with music.
View Article and Find Full Text PDFPhase-dependent plasticity has been proposed as a neurobiological mechanism by which oscillatory phase-amplitude cross-frequency coupling mediates memory process in the brain. Mimicking this mechanism, real-time EEG oscillatory phase-triggered transcranial magnetic stimulation (TMS) has successfully induced LTP-like changes in corticospinal excitability in the human motor cortex. Here we asked whether EEG phase-triggered afferent stimulation alone, if repetitively applied to the peaks, troughs, or random phases of the sensorimotor mu-alpha rhythm, would be sufficient to modulate the strength of thalamocortical synapses as assessed by changes in somatosensory evoked potential (SEP) N20 and P25 amplitudes and sensory thresholds (ST).
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