Publications by authors named "A E Sekerci"
Introduction: Diabetes is a chronic disease with increasing prevalence. There is growing evidence pharmacist can contribute to clinical outcomes. This study aims to evaluate contribution of pharmacist to prediabetes and diabetes care.
View Article and Find Full Text PDFObjective: Cognitive impairment is increasingly recognized as a complication of diabetes, yet the underlying pathology remains unclear. This study aims to investigate the roles of inflammation, oxidative stress, endothelial dysfunction, and neuronal damage in the neuropathology underlying diabetes related cognitive impairment.
Methods: This study assessed 183 participants (54 prediabetes, 71 Type 2 diabetes mellitus [T2DM], and 58 controls) for cognitive performance using the Montreal Cognitive Assessment (MoCA).
Cognitive impairment is frequently seen in patients with type 2 diabetes (T2DM), ranging from mild impairment to dementia. However, our knowledge of the specific profiles and risk factors for these different levels of impairment is limited. In this study involving 152 patients with T2DM, cognitive function was assessed using the Montreal Cognitive Assessment test.
View Article and Find Full Text PDFAim: Although there exists substantial epidemiological evidence indicating an elevated risk of dementia in individuals with diabetes, our understanding of the neuropathological underpinnings of the association between Type-2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) remains unclear. This study aims to unveil the microstructural brain changes associated with T2DM in AD and identify the clinical variables contributing to these changes.
Methods: In this retrospective study involving 64 patients with AD, 31 individuals had concurrent T2DM.
Article Synopsis
- The study investigates the connection between cognitive impairment and Type 2 diabetes (T2DM), focusing on the role of BDNF (Brain-Derived Neurotrophic Factor) in this relationship.
- It includes 68 prediabetes patients, 96 T2DM patients, and 65 healthy controls, evaluating cognitive function using the MoCA test and measuring BDNF levels.
- Results show that T2DM patients exhibit significant cognitive impairment, especially in memory, and while BDNF levels increase in T2DM, it does not mediate the cognitive impairment associated with diabetes.