Distinct pattern and prevalence of dihydropteroate synthase gene mutations in children with sickle cell anaemia and haemoglobin AA in Benin City, Nigeria: the impact of HbAA.

Introduction: specific mutations on the Plasmodium falciparum dihydropteroate synthase (Pfdhps) gene mediate sulphadoxine/pyrimethamine (SP) resistance and thus, pose a threat to the efficacy of SP-Intermittent Preventive Therapy (SP-IPT) in malaria chemoprevention in children, including those with sickle cell anaemia (SCA). This study determined the distinct pattern and prevalence of Pfdhps mutations in children with SCA and in those with homozygous haemoglobin A (HbAA) in Benin City, Nigeria; showing the impact of haemoglobin phenotype.

Methods: this was a cross-sectional study involving children with SCA and HbAA.

An Audit of Tuberculin Skin Testing among Nigerian Children in a Tertiary Health Facility in Benin City, Nigeria.

Background: This study objective was to describe the indications for the use of Tuberculin Skin Testing (TST) and the results in order to provide information that may be useful in defining the role of TST in the investigation and control of childhood tuberculosis.

Methodology: Through a Prospective cross-sectional study an audit of TSTs carried out over a one year period (2015-2016)in a tertiary hospital was done. The indications for the TST were extracted as well as the TST readings.

Prevalence of Molecular Markers of Plasmodium Falciparum Resistance to Proguanil and Pyrimethamine in Children with Haemoglobin Phenotypes SS and AA in Benin City, Nigeria.

Background: Chemoprophylaxis against Plasmodium falciparum (Pf) is advocated in children with sickle cell anaemia (SCA). Among them, antifolates: proguanil and pyrimethamine had replaced initial chemoprophylactic drugs because of widespread resistance. In recent past, efficacy of these antifolates has also come under scrutiny due to increasing level of drug resistance.

Thermochromic Polymeric Films for Applications in Active Intelligent Packaging-An Overview.

The need for passive sensors to monitor changes in temperature has been critical in several packaging related applications. Most of these applications involve the use of bar codes, inks and equipment that involve constant complex electronic manipulation. The objective of this paper is to explore solutions to temperature measurements that not only provide product information but also the condition of the product in real time, specifically shelf-life.

Improving knowledge about breast cancer and breast self examination in female Nigerian adolescents using peer education: a pre-post interventional study.

Background: Prevention of BC of which the cornerstone is creating awareness and early detection is important in adolescents and young women because of their worse outcomes. Early detection strategies such as mammography are currently beyond the reach of most women in sub-Saharan Africa..