Publications by authors named "A E Rettie"
Article Synopsis
- - The Cytochrome P450 family of enzymes metabolizes around 80% of small molecule drugs, but genetic variants can significantly affect how these drugs are processed, leading to risks of incorrect dosing and severe side effects.
- - Using a technique called VAMP-seq, researchers measured the protein abundance of over 7,600 single amino acid variants in CYP2C19, revealing key structural features essential for enzyme function and showcasing how variants at specific positions can impact protein levels.
- - The study also compared variants in CYP2C19 and CYP2C9, showing that while most amino acid exchanges had little effect, certain changes in substrate recognition sites diminished abundance in CYP2C19, indicating evolutionary trade-offs between stability and
The Expert Panel for Cosmetic Ingredient Safety (Panel) first published a safety assessment of Sodium Dehydroacetate and Dehydroacetic Acid in 1985. The Panel previously concluded that Sodium Dehydroacetate and Dehydroacetic Acid are safe as used in the present practices of use and concentration, as stated in that report. Upon re-review in 2003, the Panel reaffirmed the original conclusion, as published in 2006.
View Article and Find Full Text PDFThe Expert Panel for Cosmetic Ingredient Safety (Panel) first published the Final Report of the safety of Isobutane, Isopentane, Butane, and Propane in 1982. The Panel previously concluded that these ingredients are considered safe as cosmetic ingredients under the present conditions of concentration and use, as described in that safety assessment. Upon re-review in 2002, the Panel reaffirmed the original conclusion, as published in 2005.
View Article and Find Full Text PDFThe Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1986 and a previous re-review in 2004, along with updated information regarding product types and concentrations of use. Considering this information, the Panel confirmed that Zinc Phenolsulfonate is safe as a cosmetic ingredient in the present practices of use and concentration as described in this report.
View Article and Find Full Text PDFThe Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1982 and a previous re-review in 2002, along with updated information regarding product types and concentrations of use. Considering this information, the Panel confirmed that Laneth-9 Acetate and Laneth-10 Acetate are safe for topical application to humans in the present practices of use and concentration as described in this report.
View Article and Find Full Text PDF