Activation of cannabinoid receptor 2 by turmeric oleoresin reduces inflammation and oxidative stress in an osteoarthritis model.

Introduction: Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the progressive degradation of articular cartilage, resulting in pain and reduced mobility. Turmeric ( L.) has been widely recognized for its anti-inflammatory and antioxidant properties, but the molecular mechanisms underlying its therapeutic effects remain inadequately explored.

A comprehensive study on MDP effects: Microshear bond strength and fatigue resistance in 4YSZ ceramics.

The aim of this study is to assess the presence of MDP at various stages of the bonding procedure, enhance the adhesive and mechanical behavior of cemented zirconia ceramics. Fifty ceramic slices (15 × 15 × 2 mm) and 48 discs (Ø= 10 mm, 1 mm thickness) were prepared, sintered, air-abraded with aluminum oxide, and allocated considering: 1) microshear bond strength (µSBS) between ceramic slices and luting agent cylinders (height= 1 mm, Ø= 1.2 mm); 2) fatigue behavior, ceramic discs paired and bonded onto fiber-epoxy resin discs (Ø= 10 mm, 2.

The Expression of Cannabinoid and Cannabinoid-Related Receptors on the Gustatory Cells of the Piglet Tongue.

The gustatory system is responsible for detecting and evaluating the palatability of the various chemicals present in food and beverages. Taste bud cells, located primarily on the tongue, communicate with the gustatory sensory neurons by means of neurochemical signals, transmitting taste information to the brain. It has also been found that the endocannabinoid system (ECS) may modulate food intake and palatability, and that taste bud cells express cannabinoid receptors.

A microencapsulated blend of botanicals supports weaning piglets during a lipopolysaccharide challenge by modulating liver inflammation and intestinal integrity.

This study examined the action of a blend of botanicals (BOT) against lipopolysaccharide (LPS)-induced inflammation on cultured hepatocytes and weaning piglets. In vitro studies examined HepG2 cells treated with BOT and challenged with Escherichiacoli LPS for 8 d. BOT treatment reduced IL-6 concentration in cell culture media across time (P < 0.