Publications by authors named "A E Pariente"
The drug authorization process is shifting towards a policy aimed at shortening time-to-market. While this policy facilitates early access to new treatments, it can also result in potentially insufficient knowledge of both efficacy and safety at the time of marketing. The latter is particularly true for long-term outcomes or in specific populations (e.
View Article and Find Full Text PDFIn March 2020, World Health Organization recognized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emergence as a public health emergency of international concern. One of the major preventative measures developed against coronavirus disease 2019 (COVID-19) was vaccines. To monitor their use and safety of vaccines from the first utilization in humans during clinical development phases to implementation for the general population, an enhanced national pharmacovigilance system was enabled by the French National Agency for Medicines and Health Products Safety in collaboration with the 30 Regional Pharmacovigilance Centres.
View Article and Find Full Text PDFArticle Synopsis
- Fluoroquinolone antibiotics were studied for their potential link to spontaneous pneumothorax, a condition involving air in the chest cavity, as they can cause collagen-related side effects.
- A case-time-control study using French healthcare data from 2017-2022 indicated that both fluoroquinolones and amoxicillin were associated with an increased risk of spontaneous pneumothorax, with a higher risk linked to amoxicillin.
- The findings suggest that underlying infections may be the cause of the increased risk rather than a direct harmful effect of the antibiotics, providing some reassurance regarding the safety of fluoroquinolones' impact on lung tissue.