Publications by authors named "A E Owais"
Rare and common genetic variants contribute to the risk of atrial fibrillation (AF). Although ion channels were among the first AF candidate genes identified, rare loss-of-function variants in structural genes such as have also been implicated in AF pathogenesis partly by the development of an atrial myopathy, but the underlying mechanisms are poorly understood. While truncating variants (tvs) have been causally linked to arrhythmia and cardiomyopathy syndromes, the role of missense variants (mvs) remains unclear.
View Article and Find Full Text PDFGenetics and Pharmacogenetics of Atrial Fibrillation: A Mechanistic Perspective.
JACC Basic Transl Sci
July 2024
The heritability of atrial fibrillation (AF) is well established. Over the last decade genetic architecture of AF has been unraveled by genome-wide association studies and family-based studies. However, the translation of these genetic discoveries has lagged owing to an incomplete understanding of the pathogenic mechanisms underlying the genetic variants, challenges in classifying variants of uncertain significance (VUS), and limitations of existing disease models.
View Article and Find Full Text PDFObesity is linked to an increased risk of atrial fibrillation (AF) via increased oxidative stress. While NADPH oxidase 2 (NOX2), a major source of oxidative stress and reactive oxygen species (ROS) in the heart, predisposes to AF, the underlying mechanisms remain unclear. Here, we studied NOX2-mediated ROS production in obesity-mediated AF using Nox2-knockout mice and mature human induced pluripotent stem cell-derived atrial cardiomyocytes (hiPSC-aCMs).
View Article and Find Full Text PDFArticle Synopsis
- Anemia prevalence among women of reproductive age in Mexico fluctuated from 16.4% in 2006 to 11.6% in 2012, then rose to 18.3% in 2016, with little clarity on underlying causes.
- A systematic assessment analyzed survey data from 2006, 2012, and 2018, highlighting that factors such as household wealth, urban living, and past pregnancies significantly influenced hemoglobin levels.
- The study revealed ongoing regional and economic inequities, a decrease in funding for nutrition programs, and cultural challenges that necessitate enhanced focus on poverty alleviation and better family planning measures, particularly for young women.
Background: In Senegal, anemia prevalence among women of reproductive age (WRA) decreased from 59% in 2005 to 54% in 2017. However, determinants of reduction in disease burden under challenging public health conditions have not been studied.
Objective: To conduct a systematic in-depth assessment of the quantitative and qualitative determinants of anemia reduction among WRA in Senegal between 2005 and 2017.