Publications by authors named "A E Ortiz-Flores"
Purpose: Postmenopausal hyperandrogenism is a rare condition that requires identifying those women bearing a life-threatening tumor. We aimed to study diagnostic work-up and management of postmenopausal androgen excess, proposing an algorithm for clinical decision supporting.
Methods: We conducted an observational cross-sectional study and longitudinal follow-up including 51 consecutive menopausal patients reported for hyperandrogenism between 2003 and 2023 to our clinics.
Effect of Iron Depletion by Bloodletting vs. Observation on Oxidative Stress Biomarkers of Women with Functional Hyperandrogenism Taking a Combined Oral Contraceptive: A Randomized Clinical Trial.
J Clin Med
July 2022
Women with functional hyperandrogenism show both increased markers of oxidative stress and a mild iron overload. Combined oral contraceptives (COC) may worsen redox status in the general population. Since iron depletion ameliorates oxidative stress in other iron overload states, we aimed to address the changes in the redox status of these women as a consequence of COC therapy and of bloodletting, conducting a randomized, controlled, parallel, open-label clinical trial in 33 adult women with polycystic ovary syndrome or idiopathic hyperandrogenism.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated how reliable different ultrasound methods are for measuring ovarian stromal area (SA), stromal-to-ovarian area ratio (S/A), and echogenicity (SEcho) in diagnosing polycystic ovary syndrome (PCOS).
- Five raters used three methods for SA and S/A, and one for SEcho on 30 ovarian cineloops, comparing results under varying imaging conditions to determine consistency and agreement.
- Results showed that Method 1 for SA provided better reliability than the other methods, but overall reproducibility for all assessments, including SEcho, was rated as moderate to poor, suggesting a need for optimization in clinical practice.
Normoferritinemic women with functional hyperandrogenism show a mild iron overload. Iron excess, hyperandrogenism, and cardioautonomic dysfunction contribute to blood pressure (BP) abnormalities in these patients. Furthermore, combined oral contraceptives (COC) prescribed for hyperandrogenic symptoms may worse BP recordings.
View Article and Find Full Text PDFContext: Functional hyperandrogenism may be associated with a mild increase in body iron stores. Iron depletion exerts a beneficial effect on metabolic endpoints in other iron overload states.
Objectives: (i) To determine the effect of iron depletion on the insulin sensitivity and frequency of abnormal glucose tolerance in patients with functional hyperandrogenism submitted to standard therapy with combined oral contraceptives (COC).