Inter-Institutional Dynamics and Impact of Fluconazole-Resistant Candida parapsilosis.

Background: Infections with fluconazole-resistant Candida parapsilosis have been increasing in Israeli hospitals with unclear implications for patient outcomes.

Objectives: To determine the frequency, mechanisms, molecular epidemiology, and outcomes of azole-resistant C. parapsilosis bloodstream infections in four hospitals in Israel.

Anaeroselena agilis gen. nov., sp. nov., a Novel Sulfite- and Arsenate-Respiring Bacterium Within the Family Acetonemataceae Isolated from a Thermal Spring of North Ossetia.

A novel Gram-negative, motile, rod-shaped bacterium, designated 4137-cl, was isolated from a thermal spring of North Ossetia (Russian Federation). Strain 4137-cl grew at 30-50 °C (optimum 42 °C) with 0-3.5% NaCl (optimum 0-0.

Electrochemical Synthesis of 3-(Sulfonyl)quinol-4-ones from -Alkynyl--(formyl)anilides and Sulfinates.

Electrolysis of -alkynyl--(formyl)anilides and sodium sulfinates on graphite electrodes delivers biologically sound 3-(sulfonyl)quinol-4-ones with moderate to good yields. The reaction is carried out in an undivided cell in the presence of silver(I) oxide with potassium iodide or sodium tetrafluoroborate as the supporting electrolyte. The reaction tolerates variously substituted anilides as well as aryl and alkyl sulfinates.

Total synthesis of the taraxacine A natural product Ag(I)-catalysed imidate-alkyne cyclization.

A domino approach towards β-carboline natural product taraxacine A and its analogues was developed. The main step relies on a silver(I) and base co-catalysed imidate-alkyne cyclization. The reaction tolerates primary and secondary alcohols, and various substitutions in the indole are possible.

Diverse Cyclization Pathways Between Nitriles with Active -Methylene Group and Ambiphilic 2-Pyridylselenyl Reagents Enabled by Reversible Covalent Bonding.

Herein, we describe a novel coupling between ambiphilic 2-pyridylselenyl reagents and nitriles featuring an active α-methylene group. Depending on the solvent employed, this reaction can yield two distinct types of cationic pyridinium-fused selenium-containing heterocycles, 1,3-selenazolium or 1,2,4-selenadiazolium salts, in high yields. This is in contrast to what we observed before for other nitriles.