Publications by authors named "A E Norwood"

The prevalence of HIV is higher in the transgender population than in the general population, and pre-exposure prophylaxis (PrEP) is an effective biomedical HIV prevention strategy for the prevention of HIV. However, the transgender and gender-expansive community faces several challenges to PrEP uptake and adherence. This community-based participatory study was conducted to understand preferences for long-acting PrEP modalities better.

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Background: Genome-wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant-based genome-wide association studies improving our understanding of the genetics of CAD, the contribution of structural variants (SVs) to the risk of CAD remains largely unclear.

Method And Results: We leveraged SVs detected from high-coverage whole genome sequencing data in a diverse group of participants from the National Heart Lung and Blood Institute's Trans-Omics for Precision Medicine program.

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Rationale: Robust COVID-19 outcomes classification is important for ongoing epidemiology research on acute and post-acute COVID-19 conditions. Protocolized medical record review is an established method to validate endpoints for clinical trials and cardiovascular epidemiology cohorts; however, a protocol to adjudicate hospitalizations for COVID-19 among epidemiology cohorts was lacking.

Objectives: We developed a protocol to ascertain and adjudicate hospitalized COVID-19 across a meta-cohort of 14 US prospective cohort studies.

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Importance: Persistent symptoms and disability following SARS-CoV-2 infection, known as post-COVID-19 condition or "long COVID," are frequently reported and pose a substantial personal and societal burden.

Objective: To determine time to recovery following SARS-CoV-2 infection and identify factors associated with recovery by 90 days.

Design, Setting, And Participants: For this prospective cohort study, standardized ascertainment of SARS-CoV-2 infection was conducted starting in April 1, 2020, across 14 ongoing National Institutes of Health-funded cohorts that have enrolled and followed participants since 1971.

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Article Synopsis
  • Inflammation biomarkers offer crucial insights into the inflammatory processes linked to various diseases, and their sequencing can help reveal the genetic makeup of these traits.
  • A study analyzed 21 inflammation biomarkers from around 38,465 individuals, discovering 22 significant associations across 6 inflammatory traits after considering existing findings.
  • The research combined single-variant and rare variant analyses, identifying additional significant associations and highlighting the complexity and diversity of genetic influences on inflammation traits across different ancestries.
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