Publications by authors named "A E Mayfield"
Background: Individuals who gave birth from May 2021 through July 2021 at Atrium Health Wake Forest Baptist (AHWFB) Hospital were surveyed to identify barriers to prenatal care (PNC), assess adequacy of PNC, and examine how these measures relate to race, ethnicity, and income.
Methods: A survey was administered to 200 individuals giving birth at AHWFB. Eligibility included English- or Spanish-speaking, aged 18 years or older, and a gestational age of 35 weeks or greater at delivery.
Biomolecular condensates (BMCs), play significant roles in organizing cellular functions in the absence of membranes through phase separation events involving RNA, proteins, and RNA-protein complexes. These membrane-less organelles form dynamic multivalent weak interactions, often involving intrinsically disordered proteins or regions (IDPs/IDRs). However, the nature of these crucial interactions, how most of these organelles are organized and are functional, remains unknown.
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- - NF2-Related Schwannomatosis is a genetic disease linked to mutations in the merlin gene, which is crucial for preventing tumors, particularly bilateral vestibular schwannomas.
- - Researchers used human induced pluripotent stem cells (hiPSCs) to study how these NF2 mutations affect Schwann cells, revealing that NF2 mutant Schwann cells display abnormal shapes and increased growth.
- - The study identified new interaction partners for the merlin protein, specifically Arkadia and SKOR2, and found that their interaction is essential for properly activating a specific pathway involved in cell signaling.
The laurel wilt disease complex is a destructive combination of a non-native beetle vector [redbay ambrosia beetle (RAB), Xyleborus glabratus Eichhoff (Coleoptera: Curculionidae: Scolytinae)] and a symbiotic fungus (Harringtonia lauricola (Ophiostomataceae) T.C. Harr.
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- RIPTACs (Regulated Induced Proximity Targeting Chimeras) are innovative small molecules designed to create stable complexes between a target protein found in tumor cells and a widely expressed essential protein, leading to cancer cell death.
- This approach targets proteins that are specifically expressed in cancer cells without needing them to be the main drivers of the disease, thus offering a new strategy for cancer treatment.
- In the study, RIPTACs were engineered with ligands linked to various effector molecules, demonstrating selective accumulation in target-expressing cells and effectively inducing an anti-proliferative effect.