Does Prior Nasal Airway Surgery Impact Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea?

Objective: Nasal surgery can improve patient-reported obstructive sleep apnea (OSA) outcomes as well as adherence with medical device treatments. The aim of this study was to examine whether previous nasal surgery was associated with hypoglossal nerve stimulation (HNS) therapy outcomes.

Study Design: Retrospective observational cohort study was performed utilizing the multicenter international HNS registry (ADHERE).

A GFP splicing reporter in a coilin mutant background reveals links between alternative splicing, siRNAs, and coilin function in Arabidopsis thaliana.

Coilin is a scaffold protein essential for the structure of Cajal bodies, which are nucleolar-associated, nonmembranous organelles that coordinate the assembly of nuclear ribonucleoproteins (RNPs) including spliceosomal snRNPs. To study coilin function in plants, we conducted a genetic suppressor screen using a coilin (coi1) mutant in Arabidopsis thaliana and performed an immunoprecipitation-mass spectrometry analysis on coilin protein. The coi1 mutations modify alternative splicing of a GFP reporter gene, resulting in a hyper-GFP phenotype in young coi1 seedlings relative to the intermediate wild-type level.

A new specimen of Solnhofia parsonsi from the Upper Jurassic (Kimmeridgian) Plattenkalk deposits of Painten (Bavaria, Germany) and comments on the relationship between limb taphonomy and habitat ecology in fossil turtles.

The limestones of the Solnhofen area in southern Germany are one of the most important fossil Lagerstätten from the entire Mesozoic era, especially famous for the exquisitely preserved vertebrates. The turtles from the Solnhofen Limestone have been always of special interest because they include some of the best-preserved specimens from the Mesozoic. Here, we describe a new turtle specimen from the Torleite Formation (Kimmeridgian) of Painten and refer it to the thalassochelydian turtle Solnhofia parsonsi based on the presence of a unique combination of characters.

The smallest eating the largest: the oldest mammalian feeding traces on dinosaur bone from the Late Jurassic of the Junggar Basin (northwestern China).

Reconstructing trophic interactions in ancient ecosystems is an important and fascinating branch of palaeontological research. Here we describe small bioerosional traces that are preserved on sauropod bone from the early Late Jurassic Qigu Formation (Oxfordian) of Liuhuanggou gorge in the southern Junggar Basin (Xinjiang Province, northwestern China). The most likely producers of these traces are tiny Mesozoic mammals as evinced by the small size of the traces as well as by their paired and opposed arrangement.