[Experience of olokizumab use in COVID-19 patients].

Unlabelled: Most subjects with the COVID-19 experience mild to moderate symptoms, but approximately 10% of cases suffer from severe course of disease. IL-6 inhibitors are actively used to neutralize and prevent the cytokine storm. Olokizumab is a humanized monoclonal antibody belonging to the G4/Kappa immunoglobulin isotype that selectively binds to human IL-6 and effectively neutralizes it.

Circadian dynamics in the functional interaction of the lateral teeth occlusal surfaces' relief.

Aim: This study describes the relationship of the chronophysiological organization of the lateral teeth occlusion and the parameters of the chewing unit of the human dentofacial system (bioelectric potentials, the force of the masticatory muscles, masticatory efficiency) which should be considered in modeling of prosthesis occlusal surfaces.

Materials And Methods: Examination of 200 respondents with a "day" chronotype, with Angle class I bilateral occlusion at the age of 18-35 years was conducted daily for 3 days. From 8.

Obstructive bronchitis and recurrent pneumonia in esophageal achalasia in a child: A CARE compliant case report.

Rationale: Esophageal achalasia is characterized by impaired relaxation of the cardia and dilation of the intrathoracic part of the esophagus. We describe the late presentation of achalasia in an 11-year old girl.

Patient Concerns: She suffered from recurrent pneumonia, obstructive bronchitis, and problems with swallowing solid food.

Osteogenic differentiation of mouse bone marrow stromal cells on fibroin microcarriers.

We investigated the proliferation and osteogenic differentiation of mesenchymal stem cells cultured on fibroin microcarriers. Effective cell proliferation on the surface of the microcarriers, determined by the large surface area, and the contribution of microcarrier mineralization to the stimulation of the osteogenic differentiation of mesenchymal stem cells was revealed.

Regeneration of jejunal wall defect using an implant based on silk fibroin fibers.

Regenerative properties of fibroin implant vitalized with allogeneic bone marrow cells were assessed. The study was performed using the experimental model of rat jejunum wall damage. Three weeks after surgery, we observed recovery of all layers of the jejunum wall at the site of injury and complete degradation of the implant material.