Publications by authors named "A E Mamedov"
Article Synopsis
- Myelodysplastic syndromes (MDSs) treatment aims to improve patients' quality of life (QOL), especially concerning issues such as anemia and transfusion dependence.
- A study involving 1120 MDS patients revealed that those who maintained transfusion independence (TI) had better overall survival (OS) and QOL compared to those remaining transfusion dependent (TD), while those switching between these statuses had intermediate results.
- Specifically, patients who transitioned from TD to TI experienced improved QOL, while those moving to TD reported declines in their global QOL, especially in areas like fatigue and daily functioning.
Mitochondrial respiratory pathways in immature rat heart tissue using different cardioplegic solutions.
Gen Thorac Cardiovasc Surg
November 2024
Article Synopsis
- Minor defects in the mitochondrial ATP-generating system can harm heart function in immature hearts, so this study explored various cardioplegic solutions.
- The experiment involved 41 male rats and compared the effects of three solutions (St. Thomas, Custodiol HTK, and Del Nido) during 1-hour and 3-hour ischemic periods.
- Results showed that the Del Nido solution offered the best mitochondrial respiration and ATP production compared to the other solutions, particularly after extended ischemia.
Background And Purpose: Data is needed regarding the use of ultrahypofractionated radiotherapy (UHRT) in the context of prostate cancer elective nodal irradiation (ENI), and how this compares to conventionally fractionated radiotherapy (CFRT) ENI with CFRT or moderately hypofractionated radiotherapy (MHRT) to the prostate.
Materials And Methods: Between 2011-2019, 3 prospective clinical trials of unfavourable intermediate or high-risk prostate cancer receiving CFRT (78 Gy in 39 fractions to prostate; 46 Gy in 23 fractions to pelvis), MHRT (68 Gy in 25 fractions to prostate; 48 Gy to pelvis), or UHRT (35-40 Gy in 5 fractions to prostate +/- boost to 50 Gy to intraprostatic lesion; 25 Gy to pelvis) were conducted. Primary endpoints included biochemical failure (Phoenix definition), and acute and late toxicities (CTCAE v3.
Stereotactic Radiation Therapy for Localized Prostate Cancer: 10-Year Outcomes From Three Prospective Trials.
Int J Radiat Oncol Biol Phys
September 2024
Purpose: SABR is growingly accepted for the treatment of localized prostate cancer with recent randomized trials showing noninferiority compared with conventional or moderately hypofractionated radiation therapy. The natural history of prostate cancer necessitates extended surveillance for recurrence; however, there are a few prospective studies reporting long-term outcomes.
Methods And Materials: This study included patients with low- and intermediate-risk localized prostate cancer from 3 Canadian clinical trials enrolled from 2006 to 2013.