Experimental osteoporosis and its correction.

Osteoporosis was modeled in rats by chronic (6 months) treatment with omeprazole or serotonin, and bone tissue status was studied in experimental hepatic fibrosis and during serotonin treatment under conditions of hepatic fibrosis. Serum levels of calcium, phosphorus, alkaline phosphatase, albumins, and creatinine and bone tissue levels of calcium, phosphorus, magnesium, and iron were measured. Treatment with mesenchymal stem cells over 6 months reduced the severity of osteoporosis.

[Nervous regulation of bone metabolism].

This review is focused on the issues pertaining to the control of bone metabolism by adrenergic and serotoninergic regions of the vegetative nervous system. It is shown that mediators, enzymes, and receptors of these regions regulate bone remodeling processes. Data on the effects of regulatory peptides and nitric oxide on bone cells are presented.

[Mechanism of stimulation of the motor activity of the stomach by the greater splanchnic nerve].

The activating effect of the splanchnic nerve on motor activity of the gastro-intestinal tract could not be eliminated either with bilateral vagotomy or separate or joint administration of ornid and benzohexonium, but could be well prevented with atropin blockade of the vegetative ganglia M-serotoninergic receptors as well as diprazin blockade of the smooth muscle D-serotoninergic receptors. The data obtained reveal non-cholinergic and non-adrenergic fibers in the thoracic portion of the major splanchnic nerve which exert obvious activating effect on the stomach contractile function, serotonin being their transmitter.

[Mechanism of the intracardiac interactions of the vagus and sympathetic nerves: is a serotoninergic mechanism possible?].

A study was made of the conditions of the occurrence and mechanisms of the enhancement by the sympathetic nerve of the vagus-induced inhibition of rabbit heart work. It was discovered that to obtain such a phenomenon, it is necessary that stimulation of the stellate ganglion be made in the presence of perithreshold stimulation of the vagus after blockade of beta-adrenoreceptors. The inhibitory effect was not abolished by dihydroergotoxin but was blocked by promedol, aminazine and diprazine.