Pupil old/new effect as an objective measure of recognition memory: a meta-analysis of 17 eye-tracking experiments.

Recognition memory, the ability to recognise previously encountered information, correlates with pupil diameter changes during the recognition period. This physiological response, known as the pupil old/new effect, generally reflects the variation in pupil dilation when encountering previously studied (old) stimuli compared to new stimuli. To develop a more precise understanding of the pupil old/new effect, we conducted a meta-analysis of 17 eye-tracking experiments (across 12 articles spanning from 2008 to 2023) involving 560 healthy adults with a mean age of 22.

Cognitive exertion affects the appraisal of one's own and other people's pain.

Correctly evaluating others' pain is a crucial prosocial ability. In both clinical and private settings, caregivers assess their other people's pain, sometimes under the effect of poor sleep and high workload and fatigue. However, the effect played by such cognitive strain in the appraisal of others' pain remains unclear.

A Split-Marker System for CRISPR-Cas9 Genome Editing in Methylotrophic Yeasts.

Methylotrophic yeasts such as and (sin. and , respectively) are commonly used in basic research and biotechnological applications, frequently those requiring genome modifications. However, the CRISPR-Cas9 genome editing approaches reported for these species so far are relatively complex and laborious.

A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging.

The complex functions of neuronal synapses depend on their tightly interconnected protein network, and their dysregulation is implicated in the pathogenesis of autism spectrum disorders and schizophrenia. However, it remains unclear how synaptic molecular networks are altered biochemically in these disorders. Here, we apply multiplexed imaging to probe the effects of RNAi knockdown of 16 autism- and schizophrenia-associated genes on the simultaneous joint distribution of 10 synaptic proteins, observing several protein composition phenotypes associated with these risk genes.

[Prognostic impact of uric acid in patients with acute decompensated heart failure].

Aim: To evaluate the prognostic impact of serum uric acid (SUA) on clinical outcomes in patients with acute decompensated heart failure, as well as identify the correlation between hyperuricemia and renal function and diuretic resistance in these patients.

Materials And Methods: The study included 175 patients (125 men and 50 women) with NYHA class IIIV acute decompensated heart failure. Median age was 64 (5675) years.