In vivo, online label-free monitoring of heterogenous oxygen utilization during phototherapy with real-time ultrasound-guided photoacoustic imaging.

Understanding the tumor microenvironment, particularly the vascular density and the availability of oxygen, is key in individualizing treatment approaches and determining their efficacy. While there are many therapies including radiotherapy that are ineffective in hypoxic tumor microenvironments, here we demonstrate the heterogeneous oxygen consumption during photodynamic therapy (PDT), a non-invasive treatment method using localized light to activate a photosensitive drug in the presence of oxygen that has shown high effectiveness in the treatment of various types of tumors, including those presented in head and neck cancer (HNC) patients. While our previous work has demonstrated that blood oxygen saturation (StO) mapped before and after treatment with ultrasound-guided photoacoustic imaging (US-PAI) can be used as a surrogate marker for the regionalized long-term efficacy of PDT, real-time monitoring of StO during PDT could provide additional insights on oxygen consumption and inform dose design for "on the spot" treatment decisions.

Movement of the endoplasmic reticulum is driven by multiple classes of vesicles marked by Rab-GTPases.

Peripheral endoplasmic reticulum (ER) tubules move along microtubules to interact with various organelles through membrane contact sites. Traditionally, ER moves by either sliding along stable microtubules via molecular motors or attaching to the plus ends of dynamic microtubules through tip attachment complexes (TAC). A recently discovered third process, hitchhiking, involves motile vesicles pulling ER tubules along microtubules.

A novel approach using cyanoacrylate ester fuming on surfaces with anti-climb paint.

The use of fingermarks as evidence in forensic science remains indispensable with these being used for identification and/or elimination purposes. A wide array of methods and techniques have been developed to enhance, recover, and preserve fingermarks from various surfaces. However, the forensic community continues to encounter challenges when dealing with certain surfaces, among them is anti-climb paint, presenting unique difficulties due to its non-drying nature.

TRANSFORMing theory to practice: Developing and implementing an anti-racist, community-based racial stress and trauma group intervention for BIPOC youth.

Evidence-informed trauma interventions developed specifically and Black, Indigenous, and People of Color (BIPOC) that address racial, historical, and intergenerational trauma are sparse, particularly for youth. To meet this need, the current study developed and piloted a new intervention - (TRANSFORM) - using a and community-engaged research-to-practice approach. Across two phases, we documented the community-participatory development of TRANSFORM and analyzed preliminarily quantitative data collected in a pilot study with  = 19 BIPOC youth.