[Cerebral circulation pathophisiology into pneumocephalus craniocerebral dispoportion].

We included 19 patients with a different intensity postoperative pneumocephalus and an inadequate postoperative awakening. Intracranial CT excluded postoperative complications (oedema, haematoma, hidrocephalus) and diagnosed a pneumocephalus (above the frontal and temporal lobes and in the cerebral ventricular system). In two hours after operation we found systolic linear blood flow velocity (BFV syst.

[Pathogenesis of the vascular consequences caused by cervical instability and their algorithm for pharmacotherapy].

256 patients with radiologic detected cervical instability were examined. This pathology may be the cause of arterial or venous vertebra-basilar disorders. We realized extensive examination the patients with the cervical instability for the pathogenic correction of vascular consequences.

[The effect of the instability of cervical spine on the hemodynamics in the vertebrobasilar system].

256 patients with cephalgia were examined. The main cephalgia cause was a cervical instability. We showed importance of extended examinations for cephalgia pathogenesis.

[Influence of cortical neurotrophic factors on the neurocytokine production system in acute hemorrhagic stroke].

The mechanism of therapeutic action of cortical neurotropic factors (CNTF) was studied in hemorrhagic stroke. In intracerebral hemorrhage, CNTFs were shown to elevate the level of nerve growth factor mRNA and at the same time, produce no effect on its level in intact animals. The neuroactivating action of CNTF in the acute phase of hemorrhagic stroke was achieved by intranasal administration due to the retrograde axon transport of CNTF molecules along the olfactory nerve fibers to the brain, by passing the blood-brain barrier.

[Cytoprotective effect of neuropeptides on immunocompetent cells (in vitro study)].

Effects of the nootropic neuropeptide drugs cerebrolysin (Ebewe, Austria) and cortexin (Geterofarm, Russia) on the immunocompetent cells (T-lymphocytes of the MT-4 cell line and B-lymphocytes of the Raji cell line) were studied in vitro. The cell viability was evaluated using the MTT test by counting living and dead cells upon incubation under various conditions with a vital stain (Trypan Blue). It is established that cerebrolysin exhibits cytoprotective properties with respect to both T- and B-lymphocytes and favors the survival of immunocompetent cells.