Decarboxylation of Aza-Annulation Products as a Synthetic Route to 3-Pyrrolin-2-ones and 1,2,3,4-Tetrahydropyridin-2-ones.

Aza-annulation of enamines derived from β-ketoesters with maleic and itaconic anhydrides proceeds with excellent diastereoselectivity to provide functionalized γ- and δ-lactams. Further hydrolysis of the aza-annulation products resulted in dicarboxylic acids that underwent spontaneous decarboxylation under ambient conditions. The decarboxylation of β-γ unsaturated carboxylic acids with an electron-rich enamide C═C bond proceeds with the migration of the C═C bond and serves as a practical synthetic entry into 3-pyrrolin-2-ones and 1,2,3,4-tetrahydropyridin-2-ones.

Electrochemical synthesis of spirocyclic morpholines and tetrahydrofurans an oxidative dearomatisation strategy.

Simple and scalable electrochemical oxidation of the electron-rich benzene ring followed by intramolecular capture of reactive cation-radical intermediates opens access to spirocyclic morpholines and tetrahydrofurans. The obtained molecules can be readily modified to value-added building blocks.

[Clinical results of cardiac valve repair with bicuspid full-flow mechanical prosthesis 'MedEng-ST'].

Prosthetic repair of cardiac valves with artificial mechanical prostheses is ubiquitously performed using prostheses consisting of two cusps (bicuspidal). Several years ago, new bicuspid full-flow prostheses appeared on the market. From the first use they immediately proved reliable, with stable haemodynamic characteristics.