Publications by authors named "A E Jergens"
Article Synopsis
- The evolving perception of companion animals emphasizes their importance as family members and highlights the link between gut microbiota and overall health in these animals.
- The review discusses diseases related to gut microbiome changes, including inflammatory bowel disease and obesity, and examines factors that influence gut microbiome composition like age and diet.
- It also covers detection methods for studying gut microbiota, noting their limitations, and suggests future research directions for understanding microbial interactions related to animal health.
Chronic inflammatory enteropathies (CIEs) are an important group of diseases in dogs and involve complex pathogenetic aspects. Endoscopy and histopathology are vital for documenting the disease but are less useful for subclassifying CIEs and predicting the response to treatment. However, healing of the mucosal disease process (deep remission) and ultrastructural evaluation of the mucosa have received little attention in canine CIE.
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- - Sepsis is a serious condition caused by an unbalanced immune response to infections, leading to organ dysfunction and heightened inflammation, often linked to increased reactive oxygen species (ROS) and weakened antioxidant defenses.
- - The review article examines the role of ROS in sepsis and explores the use of antioxidants with antimicrobial properties as a potential complement to standard treatments like fluids and antibiotics.
- - It discusses the pros and cons of using antioxidants in treating sepsis, noting that multiple antioxidants can work together to improve defense mechanisms, while also highlighting the promise of immunoadjuvant therapy for patients with weakened immune responses.
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from a complex interplay between mucosal immunity, environmental factors, and host genetics. Future therapeutics for GI disorders, including IBD, that are driven by oxidative stress require a greater understanding of the cellular and molecular mechanisms mediated by reactive oxygen species (ROS).
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- DNA shotgun sequencing and qPCR are used to study changes in the gut bacteria of dogs, with qPCR providing specific quantification of bacteria.
- The canine dysbiosis index (DI), a mathematical tool based on qPCR data, evaluates fecal microbiota differences among dogs and is correlated with changes seen in sequencing.
- Results show that dogs with a dysbiosis index indicating an imbalance in microbiota have lower diversity in their gut bacteria, and higher DI values correspond to more significant microbiota shifts, marking qPCR-based DI as a reliable indicator for these changes.