Publications by authors named "A E Herr"
Bulk methods to fractionate organelles lack the resolution to capture single-cell heterogeneity. While microfluidic approaches attempt to fractionate organelles at the cellular level, they fail to map each organelle back to its cell of origin-crucial for multiomics applications. To address this, we developed VacTrap, a high-throughput microfluidic device for isolating and spatially indexing single nuclei from mammalian cells.
View Article and Find Full Text PDFBackground: A large number of individuals suffer from post-COVID-19 condition (PCC), characterised by persistent symptoms following a SARS-CoV-2 infection with an impact on daily personal and professional activities. This study aims at examining which (health) care services are used by PCC patients in the German federal state of Lower Saxony, and how these patients manage their condition. The perspectives of patients, informal caregivers and general practitioners (GPs) will be considered.
View Article and Find Full Text PDFBackground And Aims: Endoscopic sleeve gastroplasty (ESG) is a minimally invasive bariatric procedure that the gastric cavity to facilitate weight loss. We aimed to evaluate the long-term effects of ESG as a monotherapy on obesity-related comorbidities over five years.
Methods: This prospective study analyzed data from 404 consecutive patients (45±11.
Article Synopsis
- Cells are crucial for studying health and diseases, but traditional models are limited in their ability to accurately represent cell function and behavior.
- Advances in AI and omics technology enable the development of AI virtual cells (AIVCs), complex models that simulate molecular, cellular, and tissue behavior across various conditions.
- The creation of AIVCs aims to enhance biological research by allowing detailed simulations, speeding up discoveries, and promoting collaborative and interdisciplinary approaches in open scientific research.
The accumulation-associated protein (Aap) is the primary determinant of Staphylococcus epidermidis device-related infections. The B-repeat superdomain is responsible for intercellular adhesion that leads to the development of biofilms occurring in such infections. It was recently demonstrated that Zn-induced B-repeat assembly leads to formation of functional amyloid fibrils, which offer strength and stability to the biofilm.
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