Publications by authors named "A E Hadjinicolaou"
Epileptic spasms (ES) are a unique seizure type typically presenting in the form of infantile epileptic spasms syndrome (IESS) with characteristic hypsarrhythmia on scalp EEG and a preponderance with developmental delay or regression. While pharmacotherapy is the mainstay of treatment, surgical options, including disconnective or resective procedures, are increasingly recognized as viable therapeutic options for recurrent or persistent ES. However, limited data on safety, effectiveness, and prognostic factors hinder informed decision-making regarding surgery indications, timing, and intervention type.
View Article and Find Full Text PDFObjective: There has been rapid advancement in the development of deep brain stimulation (DBS) as a treatment option for adults for neurological and neuropsychiatric conditions. Here, we present a scoping review of completed and ongoing clinical trials focused on DBS in pediatric populations, highlighting key knowledge gaps.
Methods: Three databases (PubMed, OVID, and Embase) and the clinicaltrials.
Epilepsy is a neurological disorder characterized by recurring seizures that can cause a wide range of symptoms. Stereo-electroencephalography (SEEG) is a diagnostic procedure where multiple electrodes are stereotactically implanted within predefined brain regions to identify the seizure onset zone, which needs to be surgically removed or disconnected to achieve remission of focal epilepsy. This procedure is complex and challenging due to two main reasons.
View Article and Find Full Text PDFBackground And Objectives: There is a paucity of data directly comparing the outcome of surgical techniques available for the treatment of hypothalamic hamartomas (HHs). This study aims to evaluate the safety and efficacy of commonly used surgical approaches in the treatment of HH-related epilepsy.
Methods: A systematic review and individual participant data (IPD) meta-analysis was conducted.
Article Synopsis
- Microsurgical resection of epilepsy-related lesions carries risks of motor impairment, prompting the exploration of less invasive options like MRI-guided laser interstitial thermal therapy (MRgLITT) which has shown improved neurological outcomes.
- A case study of a 17-year-old athlete highlighted the use of advanced tractography techniques to map the corticospinal tract (CST), aiding in presurgical planning and guiding the MRgLITT procedure.
- The integration of CST tractography proved to be effective in enhancing the MRgLITT process, allowing for successful tumor ablation while preserving motor function, although challenges in tractography accuracy and thermal output predictability remain to be addressed.