Publications by authors named "A E Grulich"
Article Synopsis
- Australia struggles to effectively monitor the HIV epidemic due to insufficient population data, prompting this study to use incidence prevalence ratios (IPRs) to assess the epidemic trends among specific groups: men who have sex with men, women, and people who inject drugs.
- The study employed mathematical modeling to create IPRs from various data sources, comparing them against benchmarks based on life expectancy after HIV acquisition, illuminating trends from 2015 to 2022.
- The findings showed a significant decline in IPRs across all groups, with overall rates dropping by 80%, and many groups surpassing benchmarks, indicating a positive trend in managing HIV transmission in Australia.
Introduction: There are no longitudinal HIV incidence data among men who have sex with men (MSM) and transgender women (TGW) in Indonesia. We aimed to estimate HIV prevalence and incidence and identify associated factors among clinic attendees in Jakarta and Bali.
Methods: We conducted a retrospective cohort study using medical records from five clinics.
Article Synopsis
- The study analyzed the effectiveness of subsidised HIV pre-exposure prophylaxis (PrEP) in Australia from April 2018 to March 2023, focusing on HIV incidence among users over a 5-year period.
- A total of 66,206 people were included in the study, with an overall HIV incidence rate of 1.07 per 1000 person-years, indicating that higher adherence to PrEP substantially reduced the risk of HIV acquisition.
- Key factors influencing HIV acquisition included previous treatment for hepatitis C, younger age (18-29), and attending prescribers in areas with lower prevalence of gay men.
Anal high-risk human papillomavirus (HRHPV) testing-based anal cancer screening gay and bisexual men (GBM) is associated with high sensitivity, but low specificity. We report the potential role of triage use of anal cytology with HRHPV testing in detecting 12-month persistent anal high-grade squamous epithelial lesions (HSIL) in a cohort of GBM in Sydney, Australia. Participants were GBM from the Study of the Prevention of Anal Cancer (SPANC) who underwent annual anal HPV testing, cytology, and high-resolution anoscopy (HRA)-guided histology.
View Article and Find Full Text PDFAnal squamous cell carcinoma (ASCC) incidence is increasing globally. International consensus guidelines published in 2024 include HPV and/or cytology testing of anal swabs in those at greatest risk of ASCC. Self-collected anal swabs may be important for increasing screening uptake, but evidence is needed as to their equivalence to clinician-collected swabs.
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