Publications by authors named "A E Girling"
Optimal study designs for cluster randomised trials: An overview of methods and results.
Stat Methods Med Res
November 2023
Article Synopsis
- - The article reviews different designs for cluster randomised trials, focusing on the timing of control and intervention states, observation frequency, and the complexity of identifying efficient designs due to correlated observations.
- - It presents three main classes of methods for optimizing trial designs: exact formulae for treatment effect variance, generalised weight estimation for experimental units, and combinatorial optimisation algorithms to choose the best subset of units.
- - The authors also discuss techniques for adjusting experimental weights, applying concepts to non-Gaussian models, and demonstrate their findings through various cluster trial examples, including optimal allocation and observation strategies for different covariance structures.
Objectives: To explore the effect of introducing 24/7 resident labour ward consultant presence on neonatal and maternal outcomes in a large obstetric unit in England.
Design: Retrospective time sequence analysis of routinely collected data.
Setting: Obstetric unit of large teaching hospital in England.
A recent systematic review identified few papers on the economic evaluation of systems for emergency transport of acutely ill or injured patients. In addition, we found no articles dealing with the methodological challenges posed by such studies in low-income or middle-income countries. We therefore carried out an analysis of issues that are of particular salience to this important topic.
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