Modeling the architecture of the regulatory system controlling methylenomycin production in .

Background: The antibiotic methylenomycin A is produced naturally by Streptomyces coelicolor A3(2), a model organism for streptomycetes. This compound is of particular interest to synthetic biologists because all of the associated biosynthetic, regulatory and resistance genes are located on a single cluster on the SCP1 plasmid, making the entire module easily transferable between different bacterial strains. Understanding further the regulation and biosynthesis of the methylenomycin producing gene cluster could assist in the identification of motifs that can be exploited in synthetic regulatory systems for the rational engineering of novel natural products and antibiotics.

The relationship of psychiatric illness with gastrointestinal disease.

Higher rates of psychiatric comorbidity as well as more impaired psychosocial adjustment occur with the functional bowel disorders and are particularly high in self-selected referral patients compared with community populations. Reciprocally, some studies show higher rates of functional bowel disturbances in patients with psychiatric diagnoses. Remaining alert for and addressing coexisting psychiatric illness will enhance treatment outcome (increased patient compliance, functioning, and satisfaction).

TILLERING AND LEAF AREA OF WINTER BARLEY EXPOSED TO SULPHUR DIOXIDE IN THE FIELD.

Winter barley (Hordeum vulgare L., cv. 'Igri'), grown as a crop in the field, was exposed to SO concentrations ranging from 40 to 200 ppb [parts per billion (10 ) by volume] above ambient.