Publications by authors named "A E Frick-Cheng"
Unlabelled: More than half of women will experience a urinary tract infection (UTI) with most cases caused by uropathogenic (UPEC). Bacterial swimming motility enhances UPEC pathogenicity, resulting in more severe disease outcomes including kidney infection. Surprisingly, the connection between motility and iron limitation is mostly unexplored despite the lack of free iron available in the host.
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- The study focuses on the structural and proteomic analysis of Cag T4SSs derived from deletion mutants.
- It emphasizes the surprising structural independence between two key subdomains: the outer membrane complex (OMC) and the pilot region (PR).
- This finding challenges previous assumptions about the interdependence of these components within the T4SS structure.
Article Synopsis
- * The OMCC consists of a 14-fold symmetric outer membrane cap (OMC), a 17-fold symmetric periplasmic ring (PR), and an undefined stalk, with specific proteins (CagY, CagX, CagM, CagT) involved in organization.
- * Cryo-electron microscopy revealed that while the PR maintains structure without some proteins, the OMC’s organization requires multiple proteins, indicating a structural independence between the OMC and PR within the Cag T4SS
Emerging roles for ABC transporters as virulence factors in uropathogenic .
Proc Natl Acad Sci U S A
April 2024
Urinary tract infections (UTI) account for a substantial financial burden globally. Over 75% of UTIs are caused by uropathogenic (UPEC), which have demonstrated an extraordinarily rapid growth rate in vivo. This rapid growth rate appears paradoxical given that urine and the human urinary tract are relatively nutrient-restricted.
View Article and Find Full Text PDFUnlabelled: More than half of all women will experience a urinary tract infection (UTI) in their lifetime with most cases caused by uropathogenic (UPEC). Bacterial motility enhances UPEC pathogenicity, resulting in more severe disease outcomes including kidney infection. Surprisingly, the connection between motility and iron limitation is mostly unexplored, despite the lack of free iron available in the host.
View Article and Find Full Text PDF